SB 218795
SB 218795 Basic information
- Product Name:
- SB 218795
- Synonyms:
-
- SB 218795
- (-)-(R)-N-(ALPHA-METHOXYCARBONYLBENZYL)-2-PHENYLQUINOLINE-4-CARBOXAMIDE
- (R)-[[(2-PHENYL-4-QUINOLINYL)CARBONYL]AMINO]-METHYL ESTER BENZENEACETIC ACID
- (-)-(R)-N-(α-Methoxycarbonylbenzyl)-2-phenylquinoline-4-carboxamide
- Benzeneacetic acid, alpha-(((2-phenyl-4-quinolinyl)carbonyl)amino)-, methyl ester, (alphar)-
- Sb 218795r
- methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate
- constriction,SB-218795,Neurokinin Receptor,Inhibitor,neurokinin-3,NK receptor,pupillary,inhibit,Tachykinin receptor,SB218795,SB 218795,NK-3
- CAS:
- 174635-53-1
- MF:
- C25H20N2O3
- MW:
- 396.44
- Mol File:
- 174635-53-1.mol
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SB 218795 Chemical Properties
- Boiling point:
- 623.7±55.0 °C(Predicted)
- Density
- 1.237±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 40 mg/mL, soluble
- form
- solid
- pka
- 11.41±0.46(Predicted)
- color
- white
MSDS
- Language:English Provider:SigmaAldrich
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SB 218795 Usage And Synthesis
Uses
SB 218795 is an NK3 receptor antagonist.
Definition
ChEBI: (2R)-2-[[oxo-(2-phenyl-4-quinolinyl)methyl]amino]-2-phenylacetic acid methyl ester is a member of quinolines.
Biological Activity
Potent, selective and competitive non-peptide NK 3 receptor antagonist (K i = 13 nM at hNK 3 ). Displays 90-fold and 7000-fold selectivity over hNK 2 and hNK 1 receptors respectively. Active in vivo , inhibiting agonist-induced pupillary constriction.
SB 218795Supplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
Shanghai T&W Pharmaceutical Co., Ltd.
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- +86 21 61551611
EMMX Biotechnology LLC
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- 888-539-0666
- info@emmx.com
Tianjin Kailiqi Biotechnology Co., Ltd.
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- 15076683720
- klq@cw-bio.com
Shanghai Chaolan Chemical Technology Center
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- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com