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4-(Trifluoromethyl)benzoic acid

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4-(Trifluoromethyl)benzoic acid Basic information

Product Name:
4-(Trifluoromethyl)benzoic acid
Synonyms:
  • 4-(trifluoromethyl)-benzoicaci
  • Benzoic acid, 4-(trifluoromethyl)-
  • 4-(TRIFLUOROMETHYL)BENZOIC ACID
  • A,A,A-TRIFLUORO-P-TOLUIC ACID
  • ALPHA,ALPHA,ALPHA-TRIFLUORO-P-TOLUIC ACID
  • PTF-BOA
  • P-TRIFLUOROMETHYLBENZOIC ACID
  • RARECHEM AL BO 0066
CAS:
455-24-3
MF:
C8H5F3O2
MW:
190.12
EINECS:
207-242-8
Product Categories:
  • Benzotrifluoride Series
  • Carboxylic Acids
  • blocks
  • Carboxes
  • Boronic Acid series
  • Phenyls & Phenyl-Het
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Carboxylic Acids
  • Phenyls & Phenyl-Het
  • API intermediates
  • bc0001
Mol File:
455-24-3.mol
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4-(Trifluoromethyl)benzoic acid Chemical Properties

Melting point:
219-220 °C(lit.)
Boiling point:
247°C 753mm
Density 
1.3173 (estimate)
Flash point:
247°C/753mm
storage temp. 
Sealed in dry,Room Temperature
pka
3.69±0.10(Predicted)
form 
Fine Crystalline Powder
color 
White to slight gray
Water Solubility 
Soluble in water.
BRN 
2049241
CAS DataBase Reference
455-24-3(CAS DataBase Reference)
NIST Chemistry Reference
«ALPHA»,«alpha»,«alpha»-trifluoro-p-toluic acid(455-24-3)
EPA Substance Registry System
Benzoic acid, 4-(trifluoromethyl)- (455-24-3)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37-24/25
WGK Germany 
3
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29163900

MSDS

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4-(Trifluoromethyl)benzoic acid Usage And Synthesis

Uses

4-(Trifluoromethyl)benzaldehyde is a reactant that has been used in the preparation of N,N'-(Arylmethylene)bisamides with cytotoxic activity as anti cancer agents.

Chemical Properties

White to light yellow crystal powde

Uses

4-(Trifluoromethyl)benzoic acid was used in the synthesis of salicylanilide 4-(trifluoromethyl)benzoates via?N,N?-dicyclohexylcarbodiimide coupling in dry N,N-dimethylformamide. It was used as internal standard during the ultra trace analysis of fluorinated aromatic carboxylic acids by GC/MS method.

Definition

ChEBI: A benzoic acid carrying a 4-trifluoromethyl substituent.

4-(Trifluoromethyl)benzoic acid Preparation Products And Raw materials

Preparation Products

4-(Trifluoromethyl)benzoic acidSupplier

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