Basic information Safety Supplier Related

KT5823

Basic information Safety Supplier Related

KT5823 Basic information

Product Name:
KT5823
Synonyms:
  • PROTEIN KINASE INHIBITOR KT 5823
  • 9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-, methyl ester, (9S,10R,12R)-
  • (9S, 10R, 12R)-2,3,9,10,11,12-HEXAHYDRO-10-METHOXY-2,9-DIMETHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-10-CARBOXYLIC ACID, METHYL ESTER
  • KT5823
  • (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
  • (9R)-2,3,9,10,11,12-Hexahydro-10β-methoxy-2,9-dimethyl-1-oxo-9α,12α-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester
  • 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-I)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-, methyl ester, (9R-(9alpha,10beta,12alpha))-
  • 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-I)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-, methyl ester, (9R,10R,12R)-
CAS:
126643-37-6
MF:
C29H25N3O5
MW:
495.53
EINECS:
603-150-0
Product Categories:
  • Cyclic Nucleotide related
  • antibiotic
  • Protein Kinase G (PKG)Cell Signaling and Neuroscience
  • Enzyme Inhibitors by Enzyme
  • Kinase/Phosphatase Biology
  • P to
  • Protein kinase CSerine/Threonine Kinase Biology
  • Protein Kinase Inhibitors
  • Serine/Threonine Kinase Inhibitors
Mol File:
126643-37-6.mol
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KT5823 Chemical Properties

Boiling point:
629.2±55.0 °C(Predicted)
Density 
1.52±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
ethyl acetate: 5 mg/mL
form 
lyophilized powder
pka
-1.01±0.60(Predicted)
color 
white
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Safety Information

Hazard Codes 
Xi
WGK Germany 
3
10
HS Code 
29349990

MSDS

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KT5823 Usage And Synthesis

Chemical Properties

Yellow powder

Uses

KT 5823 is a protein kinase inhibitor shown to increase TSH-induced NIS expression, and thus iodide uptake, in thyroid cells.

General Description

Highly specific cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM). Inhibits protein kinase C (Ki = 4.0 μM) and protein kinase A (Ki >10.0 μM) at higher concentrations.

Biological Activity

Selective inhibitor of protein kinase G (K i values are 0.23, 4 and > 10 μ M for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC 50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μ M. Also available as part of the Mixed Kinase Inhibitor Tocriset™ .

Biochem/physiol Actions

Cell permeable: yes

KT5823Supplier

Nanjing Shizhou Biology Technology Co.,Ltd Gold
Tel
025-85560043-
Email
sean.lv@synzest.com
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Email
jkinfo@jkchemical.com;market6@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Email
3bsc@sina.com
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065-
Email
3002732518@qq.com