4-AMINO-3-FORMYLPYRIDINE Chemical Properties

Melting point:

97-98

Boiling point:

342.2±27.0 °C(Predicted)

Density 

1.264±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform (Sparingly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly)

form 

Powder

pka

6.96±0.12(Predicted)

color 

White to light yellow to cream

Sensitive 

Air Sensitive

CAS DataBase Reference

42373-30-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-43-22

Safety Statements 

26-36/37/39-36/37

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2933399990

MSDS

• Language:English Provider:ALFA

4-AMINO-3-FORMYLPYRIDINE Usage And Synthesis

Uses

4-Aminonicotinaldehyde acts as a reagent used in the preparation of 2,3-disubstituted 1,6-naphthyridines as a potential diurectic agents.

Synthesis

Synthesis of Example 25C 4-Aminonicotinaldehyde: Example 25B (870 mg, 4.2 mmol) was dissolved in a 3N aqueous hydrochloric acid solution (10 mL), heated to reflux and held overnight. Upon completion of the reaction, it was extracted three times with ether to remove impurities. Subsequently, the pH of the aqueous layer was adjusted to greater than 7 with solid K2CO3 and extracted six times with a 20% isopropanol/chloroform mixture to collect the product. The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated to afford the target compound 4-amino-3-pyridinecarboxaldehyde (450 mg, 87% yield).

References

[1] Patent: US2003/187026, 2003, A1
[2] Patent: US2003/199511, 2003, A1. Location in patent: Page/Page column 24
[3] Journal of Organic Chemistry, 1983, vol. 48, # 20, p. 3401 - 3408
[4] Synthesis, 1999, # 6, p. 959 - 964
[5] Patent: WO2013/13817, 2013, A1. Location in patent: Page/Page column 144

4-AMINO-3-FORMYLPYRIDINE(42373-30-8)Related Product Information

• Methyl 4-aminopyridine-3-carboxylate
• 4-Amino-3-pyridinecarboxylic acid
• 4-(BUTYLAMINO)-1-ETHYL-6-METHYL 1H-PYRAZOLO[3,4B]PYRIDINE-5-ETHYLCARBOXYLATE HYDROCHLORIDE
• ETAZOLATE
• Triflocin
• 2-AMINO-3-FORMYLPYRIDINE,2-Amino-3-formylpyridine, 2-Aminonicotinaldehyde
• 2-AMINO-3-PYRIDINECARBOXALDEHYDE HCL
• 4-[(2,2-Dimethylpropanoyl)amino]-3-formylpyridine
• TERT-BUTYL 3-FORMYLPYRIDIN-4-YLCARBAMATE
• 2-BOC-AMINO-3-FORMYLPYRIDINE,2-N-BOC-AMINO-3-FORMYLPYRIDINE
• 4-Aminopyridine
• 3-Pyridinecarboxaldehyde
• SB 205384
• ETHYL 4-[(4-CHLOROBENZYL)AMINO]-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE
• Cartazolate
• ETHYL 4-[4-(4-CHLOROPHENYL)PIPERAZINO]-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE
• 9-AMINO-3,3-DIMETHYL-3,4-DIHYDRO-1(2H)-ACRIDINONE
• 1,6,8-TRIMETHYL-1,2,3,6-TETRAHYDRODIPYRAZOLO[3,4-B:3,4-D]PYRIDIN-3-ONE