N-BOC-4-Hydroxypiperidine Chemical Properties

Melting point:

61-65 °C (lit.)

Boiling point:

292.3±33.0 °C(Predicted)

Density 

1.107±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform, Ethyl Acetate

pka

14.80±0.20(Predicted)

form 

Powder

color 

White to cream

BRN 

7202094

InChI

InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-8(12)5-7-11/h8,12H,4-7H2,1-3H3

InChIKey

PWQLFIKTGRINFF-UHFFFAOYSA-N

SMILES

N1(C(OC(C)(C)C)=O)CCC(O)CC1

CAS DataBase Reference

109384-19-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29339900

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

N-BOC-4-Hydroxypiperidine Usage And Synthesis

Chemical Properties

White to cream powder

Uses

Used in a synthesis of N-heterocyclic alkyl ethers via the Mitsunobu reaction.

Uses

N-Boc-4-hydroxypiperidine is a 4-hydroxypyridine with a boc protecting group used in the preparation of neurologically active agents and other pharmaceutical compounds.

Preparation

A mixture of 4-hydroxypiperidine (10.0 g, 98. 9 mmol), aqueous sodiumhydrogen carbonate (150 mL, 1 M), DI-FERT-BUTYL dicarbonate (21. 6 g, 98.9 mmol) and dichloromethane was stirred for 15 h. The phases were separated and the product (N-BOC-4-Hydroxypiperidine) was isolated as an oil in quantitative yield (19.9 g).

N-BOC-4-Hydroxypiperidine(109384-19-2)Related Product Information

• 2,2,6,6-Tetramethyl-4-piperidinol
• Haloperidol
• N-Carbobenzyloxyglycine
• tert-Butyl peroxyacetate
• Triacetonediamine
• tert-Butyl acetate
• tert-Butanol
• 4-Cyanophenol
• DROPERIDOL
• 1-Boc-4-cyanopiperidine
• N-Boc-4-piperidinemethanol
• tert-Butyl 4-methylenepiperidine-1-carboxylate
• 1-Boc-3-piperidone
• Diphenoxylate
• 4-Hydroxypiperidine
• Carbonyl iron powder
• (2R,4S)-N-BOC-4-HYDROXYPIPERIDINE-2-CARBOXYLIC ACID METHYL ESTER
• 1-Boc-4-methanesulfonyloxypiperidine