SCOULERIN
SCOULERIN Basic information
- Product Name:
- SCOULERIN
- Synonyms:
-
- SCOULERIN
- SCOULERIN(SH)
- (13aS)-5,8,13,13a-tTtrahydro-3,10-diMethoxy-6H-dibenzo[a,g]quinolizine-2,9-diol
- (S)-5,8,13,13a-Tetrahydro-3,10-diMethoxy-6H-Dibenzo[a,g]quinolizine-2,9-diol
- Alkaloid HF 1, froM HunneMannia fuMariaefolia
- (-)-scoulerine
- 3,10-dimethoxy-13a-alpha-berbine-2,9-diol
- 3,10-dimethoxy-13a-alpha-berbine-9-diol
- CAS:
- 6451-73-6
- MF:
- C19H21NO4
- MW:
- 327.37
- EINECS:
- 200-258-5
- Product Categories:
-
- Aromatics
- Heterocycles
- Alkaloids
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 6451-73-6.mol
SCOULERIN Chemical Properties
- Melting point:
- 192°C
- Boiling point:
- 503.3±50.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- A crystalline solid
- pka
- 9.88±0.20(Predicted)
SCOULERIN Usage And Synthesis
Description
This form of the alkaloid is more widespread than the d-form, occurring in Corydalis caseana, C. micrantha, C. montana, C. scouleri, C. sibirica and Papaver somniferum. It has [α]26D - 318° (c 0.41, MeOH) or - 289° (c 0.62, MeOH). It forms pale grey needles when crystallized from MeOH. The hydrochloride has m.p. 268-9°C; the picrate, m.p. 206°C (dec.) and the diethyl ether, m.p. 155°C. The oxidation products are the same as for the preceding base.
Chemical Properties
Off-White to Pale Pink Solid
Uses
The S-(+)-enantiomer of Scoulerine, an alkaloid found in the opium poppy.
Uses
(S)-Scoulerine is an alkaloid found in the opium poppy. (S)-Scoulerine acts as an antagonist at the α2-adrenoceptor, α1D-adrenoceptor and 5-HT receptor.
Definition
ChEBI: A berberine alkaloid isolated from Corydalis saxicola.
References
Manske., Can. J. Res., 14B, 347, 354 (1936)
Manske., ibid, 17B, 57 (1939)
Manske., ibid, 18B, 414 (1940)
Manske., ibid, 20B, 49 (1942)
Brochmann-Hanssen, Nielsen., Tetrahedron Lett., 2261 (1966)
Synthesis:
Kametani., Japanese Patent, 70, 37,976, 10 December 1970
SCOULERINSupplier
- Tel
- 0871-65217109 13211707573;
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- Tel
- 010-82848833 400-666-7788
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- Tel
- 021-50135380
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- Tel
- +86-028-82633397 18982077548
- cwb1@biopurify.cn
- Tel
- 021-51320588
- tauto@tautobiotech.com
SCOULERIN(6451-73-6)Related Product Information
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- veratramine
- VERATRIDINE
- L-Hyoscyamine
- Daurinoline
- menisdaurin
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- (-)-STYLOPINE
- SCOULERIN
- rotundine
- 13aalpha-Berbin-1-ol, 2,3,9,10-tetramethoxy- (8CI)
- AKOS 236-26
- CYCLANOLINE CHLORIDE
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- AKOS 213-61
- SCOULERIN(REAGENT / STANDARD GRADE)
- SCOULERIN HYDROCHLORIDE