Sodium Butyrate Chemical Properties

Melting point:

250-253 °C (lit.)

Density 

1.324 g/cm3 (30℃)

storage temp. 

Store below +30°C.

solubility 

Methanol (Slightly), Water (Slightly)

form 

Amorphous Powder

color 

White

Water Solubility 

soluble

Sensitive 

Hygroscopic

BRN 

3629439

Stability:

Stable. Incompatible with strong acids.

InChI

InChI=1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1

InChIKey

MFBOGIVSZKQAPD-UHFFFAOYSA-M

SMILES

C(CC)C([O-])=O.[Na+]

LogP

0.777 (est)

CAS DataBase Reference

156-54-7(CAS DataBase Reference)

NIST Chemistry Reference

Sodium butyrate(156-54-7)

EPA Substance Registry System

Butanoic acid, sodium salt (156-54-7)

Safety Information

Hazard Codes 

Xn

Risk Statements 

36/37/38-68

Safety Statements 

37/39-26-24/25-36/37

RTECS 

ET6400000

F 

3-10

HS Code 

29156000

Hazardous Substances Data

156-54-7(Hazardous Substances Data)

MSDS

• Language:English Provider:Butyric acid sodium salt
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Sodium Butyrate Usage And Synthesis

Chemical Properties

Sodium butyrate is a white crystalline solid with an unpleasant smell that occurs in butter and animal fat as the glycerol ester. It is the sodium salt of butyric acid. It has various effects on cultured mammalian cells including inhibition of proliferation, induction of differentiation and induction or repression of gene expre.

Uses

Sodium butyrate has been used:
as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.
as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.
to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.

Uses

Sodium Butyrate is an inhibitor of histone deacetylase activity (HDAC) resulting in improvement of physiological disorders such as Duchenne muscular dystropy. In addition it is a possible antitumor agent when used in conjunction with other cytotoxic agents as they have been shown to treat carcinomas.

Definition

ChEBI: Sodium butyrate is an organic sodium salt resulting from the replacement of the proton from the carboxy group of butyric acid by a sodium ion. It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor and a geroprotector. It contains a butyrate.

benefits

Sodium butyrate, a butyrate, is used in supplements. The benefits of butyrate begin in the gut and extend to a host of other important body systems. It could fuel the gut lining, support healthy gut permeability. promote a healthy inflammation response in the gut, may fight colonic diseases and cancers, promote healthy blood sugar levels, supports normal proliferation of healthy yeast levels, promote cell differentiation, regulate the immune system , combat brain fog and improve sleep, and supports healthy blood pressure levels.

Biological Activity

Histone deacetylase inhibitor. Restores contextual memory in a transgenic mouse model of Alzheimer's disease. Shown to induce pancreatic progenitor formation. Directs the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with the cytokine Activin A.

Biochem/physiol Actions

Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range. Decreases Ca2+ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.

storage

Room temperature

Purification Methods

Sodium butyrate [156-54-7] M 110.1. Prepare it by neutralising the acid with Na2CO3, and recrystallising it from EtOH. [Beilstein 2 IV 779.]

Sodium Butyrate(156-54-7)Related Product Information

• Sodium hyaluronate
• Sodium percarbonate
• Sodium silicate
• Sodium hydroxide
• Sodium bicarbonate
• Sodium carbonate
• Butyric Acid
• Sodium chlorite
• Sodium chloride
• Trisodium citrate dihydrate
• Methyl butyrate
• Sodium acetate
• Sodium formate
• 3beta-Hydroxy-5-cholestene 3-butyrate
• Diclofenac sodium
• Sodium benzoate
• 2-Butoxyacetic acid
• n-Butylboronic acid