3-CHLORO-5-FLUOROANILINE Chemical Properties

Boiling point:

98C/19Torr

Density 

1.45

refractive index 

1.561-1.563

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

Liquid

pka

2.52±0.10(Predicted)

color 

Clear light yellow to orange

CAS DataBase Reference

4863-91-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,T

Risk Statements 

36/37/38-20/21/22-23/24/25-22

Safety Statements 

36/37/39-26-45

RIDADR 

2810

Hazard Note 

Toxic

HazardClass 

6.1

HS Code 

29214200

MSDS

• Language:English Provider:ACROS

3-CHLORO-5-FLUOROANILINE Usage And Synthesis

Chemical Properties

Clear orange liquid

Uses

3-Chloro-5-fluoroaniline is an aniline derivative with chlorine and fluorine substituents at positions 3 and 5, respectively, which can be used as a reagent for chemical reactions, as a raw material for organic synthesis, and as a component of pharmaceutical intermediates. It is widely used in the synthesis of active pharmaceutical ingredients (APIs), especially antiviral compounds against the influenza A (H1N1) virus. It is also used in the synthesis of glucocorticoid receptor agonists for the treatment of inflammation. In addition, the presence of chloro and fluorine substituents in 3-chloro-5-fluoroaniline allows for further functionalisation such as palladium-catalysed carbon-carbon coupling and nucleophilic aromatic substitution.

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