SB9200
SB9200 Basic information
- Product Name:
- SB9200
- Synonyms:
-
- SB9200
- Inarigivir soproxil
- SB9200(Inarigivir soproxil)
- SB9200;SB 9200;SB-9200
- inarigivir soproxil SB9200
- Irigivir soproxil
- Adenosine, 2'-O-methyl-P(S)-[[[(1-methylethoxy)carbonyl]oxy]methyl]-P-thiouridylyl-(3'→5')-2'-deoxy-
- GS-9992)
- CAS:
- 942123-43-5
- MF:
- C25H34N7O13PS
- MW:
- 703.62
- Mol File:
- 942123-43-5.mol
SB9200 Chemical Properties
- Density
- 1.80±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 102 mg/mL (144.96 mM)
- form
- Solid
- pka
- 9.39±0.10(Predicted)
- color
- White to off-white
SB9200 Usage And Synthesis
Uses
Inarigivir soproxil, has a broad-spectrum antiviral activity against RNA viruses including hepatitis C virus (HCV), norovirus, respiratory syncytial virus and influenza and has demonstrated activity against hepatitis B virus (HBV) in vitro and in vivo.
in vivo
The induction of host immune responses by pretreatment with Inarigivir soproxil (SB 9200) followed by Entecavir (ETV) resulted in antiviral efficacy that was superior to that obtained using the strategy of viral reduction with ETV followed by immunomodulation[2].
Sequential treatment of chronic WHV carrier woodchucks with Inarigivir soproxil (30 mg/kg)followed by ETV induced marked suppression of serum viremia and antigenemia and delayed recrudescence of viral replication compared to sequential treatment with ETV followed by Inarigivir soproxil[2].
| Animal Model: | Woodchucks chronically infected with woodchuck hepatitis virus (WHV)[2] |
| Dosage: | 30 mg/kg |
| Administration: | Orally treated once daily; group 1 received ETV for 4 weeks followed by Inarigivir soproxil for 12 weeks. Group 2 received Inarigivir soproxil for 12 weeks followed by ETV for 4 weeks |
| Result: | Both groups demonstrated marked reductions in hepatic WHV nucleic acid levels which were more pronounced in Group 2. |
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