N-(2-(2-Azidoethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide Chemical Properties

form 

Oil

color 

White to off-white

N-(2-(2-Azidoethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide Usage And Synthesis

Uses

Biotin-PEG1-azide is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Biotin-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

N-(2-(2-Azidoethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide(1204085-48-2)Related Product Information

• Biotin-PEG1-NHS ester
• Biotin-PEG1-oxyamine HCl salt
• 2-(biotinylamido)ethanol
• Biotin-PEG1-hydrazide
• Biotin-PEG1-SH
• Biotin-PEG1-TFP
• 1H-Thieno[3,4-d]iMidazole-4-pentanaMide, N-[2-(2-aMinoethoxy)ethyl]hexahydro-2-oxo-, (3aS,4S,6aR)-
• Biotin-PEG1-COOH
• Biotin-PEG1-Mal
• Biotin-PEG7-Amine
• Biotin-PEG6-t-butyl ester
• Biotinoyl tripeptide-1
• Biotin-PEG4-S-S-NHS
• Biotin-PEG3-t-butyl ester
• INDEX NAME NOT YET ASSIGNED
• BIOTIN HYDRAZIDE
• Biotin-PEG7-thiourea
• Biotin-SS-Amine HCl Salt