12-HYDROXYDODECANOIC ACID Chemical Properties

Melting point:

85-88 °C(lit.)

Boiling point:

296.74°C (rough estimate)

Density 

0.988±0.06 g/cm3 (20 ºC 760 Torr)

refractive index 

1.4410 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

4.78±0.10(Predicted)

form 

Solid

color 

White

BRN 

1238370

Stability:

Stable. Incompatible with bases, reducing agents and oxidizing agents. Combustible. May cause dust explosion when mixed with air.

InChI

1S/C12H24O3/c13-11-9-7-5-3-1-2-4-6-8-10-12(14)15/h13H,1-11H2,(H,14,15)

InChIKey

ZDHCZVWCTKTBRY-UHFFFAOYSA-N

SMILES

OCCCCCCCCCCCC(O)=O

LogP

2.866 (est)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:SigmaAldrich

12-HYDROXYDODECANOIC ACID Usage And Synthesis

Chemical Properties

white to off-white powder

Uses

12-Hydroxylauric Acid is used in the structural and functional characterization of S-nitrosoglutathione reductase from Solanum lycopersicum.

Uses

12-Hydroxydodecanoic acid was used in the synthesis of high molecular weight poly[(12-hydroxydodecanoate)-co-(12-hydroxystearate)] [poly(12HD-co-12HS)] samples with variable monomer ratios using methyl 12-hydroxystearate.

Definition

ChEBI: 12-hydroxylauric acid is a medium-chain fatty acid that is the 12-hydroxylated derivative of lauric acid. It has a role as a human metabolite. It is functionally related to a dodecanoic acid. It is a conjugate acid of a 12-hydroxylaurate.

Synthesis

In the hydrothermal reactor, terminal chlorinated dodecanoic acid and NaOH solution were added, and the reaction was stopped after hydrothermal alkaline hydrolysis at the specified temperature for a specified time, and the crude product of terminal hydroxydodecanoic acid was obtained by filtration. The pure product of terminal hydroxydodecanoic acid used for structure and purity identification was obtained by acidifying the crude product of terminal chlorinated 12-acid, and then purified by recrystallization with petroleum ether (60-90 ??), and the pure product of terminal hydroxydodecanoic acid used for application performance testing was obtained by neutralization of the above. The crude product was derivatized by methyl esterification with boron trifluoride - ether/methanol solution, extracted with anhydrous ether, and the upper ether layer was analyzed by GC for the content of each component (area normalization method), and the yield (Y) of terminal hydroxy12 acid was calculated.

IC 50

Human Endogenous Metabolite

Purification Methods

Crystallise the acid from toluene [Sadowik et al. J Am Chem Soc 108 7789 1986]. [Beilstein 3 III 658.]

12-HYDROXYDODECANOIC ACID(505-95-3)Related Product Information

• 12-HYDROXYDODECANOIC ACID
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• DIHYDROOUABAIN
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• Maslinic acid
• Dimethyl dodecanedioate
• 2-HYDROXYDODECANOIC ACID