Basic information Safety Supplier Related

Eltanolone

Basic information Safety Supplier Related

Eltanolone Basic information

Product Name:
Eltanolone
Synonyms:
  • 3alpha,5beta-Epimeric pregnanolone
  • 3alpha,5beta-Pregnanolone
  • 3-alpha-hydroxy-5-beta-pregnan-20-on
  • Pregnan-20-one, 3-hydroxy-, (3a,5b)-
  • Pregnan-3α-ol-20-one
  • 3a,5b-Epimeric pregnanolone
  • 1-[(3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
  • 5B-Pregnan-3α-ol-20-one
CAS:
128-20-1
MF:
C21H34O2
MW:
318.49
Product Categories:
  • Steroids
  • Pharmaceutical Intermediates
Mol File:
128-20-1.mol
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Eltanolone Chemical Properties

Melting point:
149°C
alpha 
D23 +59.6° (c = 0.3 in chloroform); D26 +108.5 ±1° (c = 9.23 mg/1.23 ml abs ethanol)
Boiling point:
397.64°C (rough estimate)
Density 
1.0234 (rough estimate)
refractive index 
1.5344 (estimate)
storage temp. 
Store at RT
solubility 
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka
15.12±0.70(Predicted)
form 
Solid
color 
White to Off-White
Water Solubility 
8mg/L(room temperature)
NIST Chemistry Reference
3Alpha-hydroxy-5beta-pregnan-20-one(128-20-1)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
40
Safety Statements 
22-36
WGK Germany 
3
RTECS 
TU4384000
Toxicity
LD50 in mice, rats (mg/kg): 66 ± 10, 27.5 ± 2.4 i.v. (Gyermek)

MSDS

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Eltanolone Usage And Synthesis

Uses

A hyponotic-anaesthetic agent.

Definition

ChEBI: The 3alpha-stereoisomer of 3-hydroxy-5beta-pregnan-20-one.

Biological Activity

GABA A receptor positive allosteric modulator. Neuroactive steroid.

Biochem/physiol Actions

5β-Pregnan-3α-ol-20-one or pregnanolone is a neurosteroid that acts as a positive allosteric modulator (PAMs) of γ-aminobutyric acid A receptors (GABAARs). It mediates anti-convulsive, anxiolytic and sedative effects. Pregnanolone inhibits γ-aminobutyric acid C receptor (GABAC) receptor-based response and favors GABAA?receptor-mediated currents.

storage

Store at RT

EltanoloneSupplier

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