Eltanolone Chemical Properties

Melting point:

149°C

alpha 

D23 +59.6° (c = 0.3 in chloroform); D26 +108.5 ±1° (c = 9.23 mg/1.23 ml abs ethanol)

Boiling point:

397.64°C (rough estimate)

Density 

1.0234 (rough estimate)

refractive index 

1.5344 (estimate)

storage temp. 

Store at RT

solubility 

Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)

pka

15.12±0.70(Predicted)

form 

Solid

color 

White to Off-White

Water Solubility 

8mg/L(room temperature)

NIST Chemistry Reference

3Alpha-hydroxy-5beta-pregnan-20-one(128-20-1)

Safety Information

Hazard Codes 

Xn

Risk Statements 

40

Safety Statements 

22-36

WGK Germany 

3

RTECS 

TU4384000

Toxicity

LD50 in mice, rats (mg/kg): 66 ± 10, 27.5 ± 2.4 i.v. (Gyermek)

MSDS

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Eltanolone Usage And Synthesis

Uses

A hyponotic-anaesthetic agent.

Definition

ChEBI: The 3alpha-stereoisomer of 3-hydroxy-5beta-pregnan-20-one.

Biological Activity

GABA A receptor positive allosteric modulator. Neuroactive steroid.

Biochem/physiol Actions

5β-Pregnan-3α-ol-20-one or pregnanolone is a neurosteroid that acts as a positive allosteric modulator (PAMs) of γ-aminobutyric acid A receptors (GABAARs). It mediates anti-convulsive, anxiolytic and sedative effects. Pregnanolone inhibits γ-aminobutyric acid C receptor (GABAC) receptor-based response and favors GABAA?receptor-mediated currents.

storage

Store at RT

Eltanolone(128-20-1)Related Product Information

• N-Vinyl-2-pyrrolidone
• Polyvinylpyrrolidone
• N-Methyl-2-pyrrolidone
• 1-Octacosanol
• Pregnanolone-[d5] (Solution)
• Pregnenolone
• Gestrinone
• 5BETA-PREGNANE-3ALPHA,20ALPHA-DIOL
• Gestodene
• (Z)-Guggulsterone
• GUGGULSTERONE E
• (3β,9β,10α)-3-Hydroxy-pregna-5,7-dien-20-one
• Progesterone
• 16-Dehydropregnenolone acetate
• 1-Triacontanol
• 5B-PREGNAN-3A-OL-20-ONE-17,21,21,21-D4
• Renanolone
• Allopregnanolone