Benzhydrylamine Chemical Properties

Melting point:

12 °C (lit.)

Boiling point:

295 °C (lit.)

Density 

1.063 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.595(lit.)

Flash point:

>230 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

Chloroform, DMSO, Methanol

pka

8.41±0.10(Predicted)

form 

Liquid

color 

Clear colorless to yellow

Specific Gravity

1.063

Water Solubility 

Miscible with chloroform, dimethylsulfoxide and methanol. Slightly miscible with water.

Sensitive 

Air Sensitive

Merck 

14,1076

BRN 

776434

CAS DataBase Reference

91-00-9(CAS DataBase Reference)

NIST Chemistry Reference

Aminodiphenylmethane(91-00-9)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

26-36

RIDADR 

2810

WGK Germany 

3

RTECS 

DA4407300

F 

9-23

HazardClass 

8

PackingGroup 

III

HS Code 

29214990

MSDS

• Language:English Provider:Phenylbenzenemethanamine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Benzhydrylamine Usage And Synthesis

Chemical Properties

Colorless liquid

Uses

Benzhydrylamine is fine-chemical intermediate used for chiral resolution. It acts as an active pharmaceutical ingredient intermediate. It is also employed as a building block for chemical synthesis. Further, it is used in the preparation of furan-2-carboxylic acid benzhydrylamide by reacting with furan-2-carbonyl chloride.

Synthesis Reference(s)

Tetrahedron Letters, 27, p. 3033, 1986 DOI: 10.1016/S0040-4039(00)84709-7

Synthesis

1) synthesis of diphenylketoxime
After benzophenone 10g, oxammonium hydrochloride 6g, 95% ethanol 20mL are put into reaction flask stirring and dissolving, gradation adds sodium hydrate solid 11g.Finish, reaction solution is heated to 88 DEG C of reaction 2h, then pours in dilute hydrochloric acid solution by reaction solution, occurs white solid, filter to obtain diphenylketoxime 10.7g, yield 99%.
2) synthesis of benzhydrylamine
Diphenylketoxime 0.25g, 95% ethanol 5mL are put into reaction flask, after solution change is clear, adds concentration into 5 × 10 7cFU/mL waxy Bacillus solution 50mL, constant temperature 30 DEG C (rotating speed 200r/min) oscillatory reaction in shaking table.TLC detect without raw material time, add appropriate diatomite in reaction solution and carry out centrifugation, get supernatant liquid acidifying, with dichloromethane extraction, aqueous layer basified and with dichloromethane extraction concentrate to obtain benzhydrylamine 9.0g, yield 91%.

Purification Methods

Crystallise the amine from H2O. The free base absorbs CO2 from the atmosphere; store it accordingly. The hydrochloride M 219.7 m 293-295o, crystallises from H2O. [Beilstein 12 H 1323, 12 IV 3282.]

Benzhydrylamine(91-00-9)Related Product Information

• Benzylamine
• Tris(hydroxymethyl)aminomethane
• 4,4'-Methylenedianiline
• Flunixin meglumine
• Diphenylmethane
• Trimethylamine
• Meglumine
• 4,4'-Diaminodiphenylsulfone
• Dibenzoylmethane
• p-Toluidine
• ALPHA-AMINODIPHENYLMETHANE HYDROCHLORIDE,AMINODIPHENYLMETHANE HCL,AMINODIPHENYLMETHANE HYDROCHLORIDE
• Methylamine
• 2,2-Diphenylglycine
• 9H-FLUOREN-9-AMINE
• TRT-GLY-OH
• 5,5-Diphenylhydantoin
• TRIPHENYLMETHYLAMINE
• 5-(4-METHYLPHENYL)-5-PHENYLHYDANTOIN