4-Amino-2-ethoxypyridine Chemical Properties

Melting point:

88-89 °C

Boiling point:

282.1±20.0 °C(Predicted)

Density 

1.101±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

pka

7.25±0.50(Predicted)

Appearance

White to off-white Solid

CAS DataBase Reference

89943-12-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

HS Code 

2933399990

4-Amino-2-ethoxypyridine Usage And Synthesis

Uses

4-Amino-2-ethoxypyridine is a pharmaceutical intermediate in the synthesis of other pharmaceutical compounds and is commonly used in research and chemical synthesis processes, but is not directly used as a drug to treat humans or animals.

Synthesis

The general procedure for the synthesis of 2-ethoxy-4-aminopyridine from 4-amino-2-bromopyridine is as follows: 1. 2-Bromo-4-aminopyridine (4 g), solid sodium hydroxide (4 g) and ethanol (15 ml) were placed in a reactor and heated at 160°C for 6 hrs followed by cooling to room temperature. 2. Water was added to the reaction mixture and then the solvent was partially evaporated under reduced pressure. 3. The mixture was extracted using ether and the solvent was subsequently evaporated to give a clarified oily product of 2-ethoxy-4-aminopyridine (164 g, 76% yield). 4. The oily product slowly crystallized to form colorless needle-like crystals with a melting point of 88-89 °C. The product was extracted with ether and subsequently evaporated.

References

[1] Patent: US5929082, 1999, A
[2] Recueil des Travaux Chimiques des Pays-Bas, 1951, vol. 70, p. 591,598

4-Amino-2-ethoxypyridine(89943-12-4)Related Product Information

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