3-Bromo-5-hydroxypyridine Chemical Properties

Melting point:

166-170 °C

Boiling point:

343.7±22.0 °C(Predicted)

Density 

1.788±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

8.37±0.10(Predicted)

form 

Crystalline Powder

color 

White to tan

Water Solubility 

Slightly soluble in water. Soluble in chloroform and ethyl acetate.

InChI

InChI=1S/C5H4BrNO/c6-4-1-5(8)3-7-2-4/h1-3,8H

InChIKey

VNYBIBSZZDAEOK-UHFFFAOYSA-N

SMILES

C1=NC=C(Br)C=C1O

CAS DataBase Reference

74115-13-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22-20/21/22

Safety Statements 

26-36/37/39-37-36-22

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29339900

3-Bromo-5-hydroxypyridine Usage And Synthesis

Description

3-bromo-5-hydroxypyridine is an important industrial raw material widely used in medicine, pesticides, dyes, and other industries. Since the pyridine ring has biological activity and plays an irreplaceable role in synthesising drugs that cannot be replaced by other groups or functional groups, it is a hot area in pharmaceutical research. The hydroxyl and bromine atoms in the structure of 3-bromo-5-hydroxypyridine have diverse chemical reactivity. The alcohol hydroxyl unit in its structure can undergo nucleophilic substitution reactions with common alkyl halides under alkaline conditions to obtain corresponding ether derivatives.

Chemical Properties

Light yellow needles

Uses

5-Bromo-3-methoxypyridine was refluxed with 20 mL (57%) of hydrogen bromide for 24 hours. The reaction was quenched with saturated sodium bicarbonate solution and the base mixture was extracted with 3 × 50 mL of dichloromethane. The organic fractions were pooled, dried (magnesium sulfate), filtered, and evaporated to give a white solid (3 g, >95% purity) identified as 3-bromo-5-hydroxypyridine by thin layer chromatography.

3-Bromo-5-hydroxypyridine(74115-13-2)Related Product Information

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