N-HYDROXY-BUTYRAMIDINE Chemical Properties

Melting point:

125-127℃

storage temp. 

-20°C

solubility 

H2O: ≥25mg/mL

form 

powder

color 

white to tan

Water Solubility 

H2O: ≥25mg/mL

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

N-HYDROXY-BUTYRAMIDINE Usage And Synthesis

Uses

Butyrylhydroxamic acid (N-Hydroxybutanamide) is a potent inhibitor of histone deacetylase (HDAC). Butyrylhydroxamic acid enhances memory in behavioral models of rodents and can be used as memory enhancers, mood stabilizers, and β-chain hemoglobin disease studies[1].

Biological Activity

Butyryl hydroxamic acid is a cell permeable HDAC inhibitor. Butyryl hydroxamic acid has similar potency against class I HDAC family members as 4-Phenylbutyryl hydroxamic acid (SML0026), but is approximately 5-10 fold less potent against class IIa enzymes than 4-Phenylbutyryl hydroxamic acid.

References

[1] Ruan LT, et al. A novel amidase from Brevibacterium epidermidis ZJB-07021: gene cloning, refolding and application in butyrylhydroxamic acid synthesis. J Ind Microbiol Biotechnol. 2016 Aug;43(8):1071-83. DOI:10.1007/s10295-016-1786-y

N-HYDROXY-BUTYRAMIDINE(4312-91-8)Related Product Information

• Butyramide
• BUTYRAMIDINE