1-METHYLHISTAMINE DIHYDROCHLORIDE Chemical Properties

Melting point:

>198°C (dec.)

storage temp. 

2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

powder

color 

Pale Yellow

Water Solubility 

water: 49.00-51.00mg/mL, clear, colorless to faintly yellow

Stability:

Hygroscopic

InChI

InChI=1S/C6H11N3.2ClH/c1-9-4-6(2-3-7)8-5-9;;/h4-5H,2-3,7H2,1H3;2*1H

InChIKey

AGXVEALMQHTMSW-UHFFFAOYSA-N

SMILES

NCCC1N=CN(C)C=1.[H]Cl.[H]Cl

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

2933299090

MSDS

• Language:English Provider:SigmaAldrich

1-METHYLHISTAMINE DIHYDROCHLORIDE Usage And Synthesis

Description

1-Methylhistamine is a major metabolite of histamine by histamine N-methyltransferase in the pathway of histidine metabolism. It has been used as a biomarker of histaminergic system activity in the brains of Alzheimer’s disease patients as well as those with hypersomnia and other neurological conditions.

Uses

1-Methylhistamine Dihydrochloride is a selective H1-receptor agonists. Also it has depressant effects.

Biochem/physiol Actions

Major metabolite of histamine by histamine N-methyltransferase.

IC 50

Human Endogenous Metabolite

References

[1] S.-E. LINDELL  R. W S. METABOLISM OF INJECTED [14C]HISTAMINE IN THE KIDNEY OF THE DOG[J]. British Journal of Pharmacology, 1958, 13 1: 52-53. DOI: 10.1111/j.1476-5381.1958.tb00189.x
[2] MOUHAMMAD MOTAWAJ. CSF levels of the histamine metabolite tele-methylhistamine are only slightly decreased in Alzheimer’s disease.[J]. Journal of Alzheimer’s disease?: JAD, 2010: 861-871. DOI: 10.3233/jad-2010-100381
[3] YVES DAUVILLIERS. Normal cerebrospinal fluid histamine and tele-methylhistamine levels in hypersomnia conditions.[J]. Sleep, 2012, 35 10: 1359-1366. DOI: 10.5665/sleep.2114

1-METHYLHISTAMINE DIHYDROCHLORIDE(6481-48-7)Related Product Information

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