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4-Nitrobenzyl chloroformate

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4-Nitrobenzyl chloroformate Basic information

Product Name:
4-Nitrobenzyl chloroformate
Synonyms:
  • P-NITROBENZYL CHLOROFORMATE
  • P-NITROCARBOBENZOXY CHLORIDE
  • PNBCF
  • PARA-NITROBENZYL CHLOROFORMATE
  • 4-Nitrobenzyl chloridocarbonate
  • 4-Nitrobenzyloxycarbonyl chloride
  • carbonochloridicacid,(4-nitrophenyl)methylester
  • Chloroformic acid p-nitrobenzyl ester
CAS:
4457-32-3
MF:
C8H6ClNO4
MW:
215.59
EINECS:
224-708-6
Product Categories:
  • Active Esters/Additives
  • Active Esters/AdditivesSynthetic Reagents
  • Benzene derivatives
  • Coupling
  • Peptide Synthesis
Mol File:
4457-32-3.mol
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4-Nitrobenzyl chloroformate Chemical Properties

Melting point:
32-34 °C(lit.)
Boiling point:
230°C 10mm
Density 
1.4928 (rough estimate)
refractive index 
1.552-1.556
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
Acetonitrile (Slightly), Chloroform (Slightly)
form 
powder to crystal
color 
White to Light yellow
Sensitive 
Moisture Sensitive
BRN 
912446
Stability:
Stable, but moisture-sensitive. May develop pressure in storage. Incompatible with moisture, strong bases, alcohols, amines, acids.
CAS DataBase Reference
4457-32-3(CAS DataBase Reference)
NIST Chemistry Reference
Carbonochloridic acid, (4-nitrophenyl)methyl ester(4457-32-3)
EPA Substance Registry System
Carbonochloridic acid, (4-nitrophenyl)methyl ester (4457-32-3)
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Safety Information

Hazard Codes 
C,T
Risk Statements 
34-37-23/24/25-36/37
Safety Statements 
26-36/37/39-45-38-28A-27
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
3-4.9
Hazard Note 
Corrosive/Toxic/Moisture Sensitive
HazardClass 
8
PackingGroup 
III
HS Code 
29159000

MSDS

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4-Nitrobenzyl chloroformate Usage And Synthesis

Chemical Properties

off-white to pale yellow powder

Uses

4-Nitrobenzyl Chloroformate is used in the preparation of prodrugs of cytotoxic acridines used in conjunction with enzyme prodrugs which counter carcinoma cells.

4-Nitrobenzyl chloroformate Preparation Products And Raw materials

Preparation Products

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