PYR-HIS-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2
PYR-HIS-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 Basic information
- Product Name:
- PYR-HIS-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2
- Synonyms:
-
- (d-ala(sup6))-lhrh
- (d-ala(sup6))-luteinizinghormone-releasinghormon
- (d-ala(sup6))-luteinizinghormone-releasinghormone
- wy-18186
- (D-ALA6)-GONADOTROPIN-RELEASING HORMONE
- (D-ALA6)-LHRH
- PYR-HIS-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2
- PYROGLU-HIS-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY NH2
- CAS:
- 51230-19-4
- MF:
- C56H77N17O13
- MW:
- 1196.32
- Mol File:
- 51230-19-4.mol
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PYR-HIS-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 Chemical Properties
- Density
- 1.52±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- pka
- 9.82±0.15(Predicted)
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Safety Information
- Hazard Codes
- T
- Risk Statements
- 60
- Safety Statements
- 53-22-36/37/39-45
- WGK Germany
- 3
- RTECS
- OK6400000
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PYR-HIS-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 Usage And Synthesis
Uses
[D-Ala6]-LH-RH acetate salt hydrate has been used to induce ovulation and to synchronize the reproductive cycle in Sprague-Dawley female rats.
Biochem/physiol Actions
(D-Ala6)-LH-RH is a GnRH (gonadotropin-releasing hormone) agonist. GnRH, which is also referred to as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism.
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