6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine Chemical Properties

Melting point:

205-207°C

Density 

1.09±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

7.07±0.50(Predicted)

form 

Solid

color 

White to Off-White

CAS DataBase Reference

88965-00-8(CAS DataBase Reference)

6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine Usage And Synthesis

Uses

6-Methyl-2-(4-methylphenyl)-imidazo[1,2-a]pyridine is an impurity of Zolpidem (Z650000), a selective non-benzodiazepine GABAA receptor agonist.

Biological Activity

O4I3 is a highly potent and KDM5A (JARID1A) subtype-selective H3K4 demethylase KDM5 inhibitor (KDM5A IC50 = 0.15 nM vs KDM5B/C/D IC50 = 125.2/9.76/4.7 nM, KDM4 IC50 = 249 nM, LSD1 IC50 >100 μM) th at effectively induces OCT4 expresson and improves OSKM-induced pluripotent stem cell (iPSC) reprogramming efficiency of human primary fibroblasts (50 nM) by preventing KDM5A from interfering with H3K4Me3 enrichment at the OCT4 promoter. O4I3 promotes hPSC homeostasis and represses cellular differentiation, increasing hPSCs viability up to 4-fold at a low 10 nM concentration when compared with Rock inhibitor Y-27632 treatment at 10 μM.

6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine(88965-00-8)Related Product Information

• Paraquat dichloride
• Methylparaben
• Methanol
• Acetonitrile
• 2,6-Lutidine
• Methyl acrylate
• Chlorodimethylphenylsilane
• 1-Methylimidazole
• Zolpidem tartrate
• 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid
• 2,4,6-Collidine
• Kresoxim-methyl
• Basic Violet 1
• 4-Methylpyridine
• Pyridine
• Methyl 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetate
• Methyl
• 2,2-DIBROMO-1-P-TOLYLETHANONE