Benzocyclobutyl-1-carboxylic acid Chemical Properties

Melting point:

75-77 °C (lit.)

Boiling point:

318.6±31.0 °C(Predicted)

Density 

1.310±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

4.18±0.20(Predicted)

form 

Crystalline Powder or Powder

color 

White to pale brown

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

MSDS

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Benzocyclobutyl-1-carboxylic acid Usage And Synthesis

Uses

1-Benzocyclobutenecarboxylic acid is a dynamic building block, capable of taking part in Diels-Alder reactions, and has been used to create large compounds such as cyclohexylmethylpiperidinyltriphenylpropioamide, a highly selective M3 antagonist.

Synthesis Reference(s)

Journal of the American Chemical Society, 80, p. 2257, 1958 DOI: 10.1021/ja01542a055
Tetrahedron Letters, 23, p. 3665, 1982 DOI: 10.1016/S0040-4039(00)88652-9

General Description

1-Benzocyclobutenecarboxylic acid is also refered as bicyclo[4.2.0]octa-1,3,5-triene-8-carboxylic acid.

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