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TABERSONINE

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TABERSONINE Basic information

Product Name:
TABERSONINE
Synonyms:
  • ,12-beta,19-alpha)-
  • aspidospermidine-3-carboxylicacid,2,3,6,7-tetrahydro-,methylester,(5-alpha
  • tabersonin
  • TABERSONINE
  • Aspidospermidine-3-carboxylic acid, 2,3,6,7-tetradehydro-, methyl ester, (5alpha,12beta,19alpha)-
  • TABERSONINE HYDROCHLORIDE FROM VOCANGA AFRICANA 98%
  • C09244
  • TABERSONINE(SH)
CAS:
4429-63-4
MF:
C21H24N2O2
MW:
336.44
EINECS:
224-615-0
Product Categories:
  • Herb extract
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
4429-63-4.mol
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TABERSONINE Chemical Properties

Melting point:
196 °C
Boiling point:
488.7±45.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), Ethanol (Slightly, Sonicated), Ethyl Acetate (Slightly)
form 
Solid
pka
7?+-.0.60(Predicted)
color 
Light Yellow to Dark Yellow
Stability:
Light Sensitive
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TABERSONINE Usage And Synthesis

Description

This alkaloid, found in Amsonia tabernaemontana, is difficult to obtain crystalline but the hydrochloride is readily crystallizable and has m.p. 195-6°C; [α]D - 310° (c 0.134, MeOH).

Chemical Properties

Dark Yellow Low Melting Solid

Occurrence

The seeds of Amsonia elliptica contain this N-oxide at tabersonine.

Uses

(-)-Tabersonine is one of the terpenoid indole alkaloids (TIAs) from Catharanthus roseus. (-)-Tabersonine shows hypotensive activity, anti-tumor activity, hypoglycemic, diuretic activity.

Definition

ChEBI: A monoterpenoid indole alkaloid with cytotoxic activity.

References

lanot, Paourrat, LeMen., Bull. Soc. Chim. Fr., 707 (1954)
Plat et al., Tetrahedron Lett., 271 (1962)

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