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Tripropyl orthoformate

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Tripropyl orthoformate Basic information

Product Name:
Tripropyl orthoformate
Synonyms:
  • 1,1′,1′′-[Methylidyntris(oxy)]trispropan
  • ORTHOFORMIC ACID TRI-N-PROPYL ESTER
  • ORTHOFORMIC ACID TRIPROPYL ESTER
  • ORTHOFORMIC TRIPROPYL ESTER
  • TRI-N-PROPYL ORTHOFORMATE
  • TRIPROPYL ORTHOFORMATE
  • TRIPROPOXYMETHANE
  • TNPOF
CAS:
621-76-1
MF:
C10H22O3
MW:
190.28
EINECS:
210-704-1
Product Categories:
  • Acetals/Ketals/Ortho Esters
  • Building Blocks
  • Orthoesters
  • Chemical Synthesis
  • Organic Building Blocks
  • Oxygen Compounds
  • Acetals/Ketals/Ortho Esters
  • Organic Building Blocks
  • Oxygen Compounds
Mol File:
621-76-1.mol
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Tripropyl orthoformate Chemical Properties

Boiling point:
106-108 °C/40 mmHg (lit.)
Density 
0.883 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.407(lit.)
Flash point:
162 °F
form 
Liquid
Specific Gravity
0.883
color 
Clear colorless
Sensitive 
Moisture Sensitive
BRN 
1744249
CAS DataBase Reference
621-76-1(CAS DataBase Reference)
NIST Chemistry Reference
Tripropyl orthoformate(621-76-1)
EPA Substance Registry System
Tripropyl orthoformate (621-76-1)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39-37/39
RIDADR 
1993
WGK Germany 
1
10-21
TSCA 
Yes
HS Code 
29159000

MSDS

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Tripropyl orthoformate Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

Tripropoxymethane can be used in the lipase-?catalyzed esterification aimed at the kinetic resolution of racemic acids, circumventing the adverse effects of the water formed in the course of the reaction.

Uses

Tripropyl orthoformate was used as alcohol donor to investigate the activity and enantioselectivity of Novozym 435 in the esterification of rac-fenoprofen in methylcyclohexane. It may be used as a drying agent during the synthesis of squaraine derivatives.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 3801, 1955 DOI: 10.1021/ja01619a036

General Description

Gas phase reactions of the rare earth metal cations with tripropyl orthoformate were studied by Fourier transform ion cyclotron resonance mass spectrometry.

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