Indazole Chemical Properties

Melting point:

145-148 °C (lit.)

Boiling point:

270 °C/743 mmHg (lit.)

Density 

1.4220 (rough estimate)

refractive index 

1.5500 (estimate)

Flash point:

270°C

storage temp. 

Inert atmosphere,Room Temperature

pka

14.00±0.10(Predicted)

form 

Needle-Like Crystalline Powder

color 

White to beige

Water Solubility 

SOLUBLE IN HOT WATER

Merck 

14,4936

BRN 

109676

CAS DataBase Reference

271-44-3(CAS DataBase Reference)

NIST Chemistry Reference

1H-Indazole(271-44-3)

EPA Substance Registry System

Indazole (271-44-3)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

RTECS 

NK7745000

HS Code 

29339990

MSDS

• Language:English Provider:Indazole
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Indazole Usage And Synthesis

Chemical Properties

white to beige needle-like crystalline powder

Uses

1H-Indazole is used in organic synthesis, it can react with butyryl chloride and 1-butyryl-1H-indazole. It is also used in synthesis of several small molecule inhibitors as potential cancer therapeutics.

Definition

ChEBI: 1H-indazole is an indazole. It is a tautomer of a 2H-indazole.

Synthesis Reference(s)

Journal of the American Chemical Society, 79, p. 5242, 1957 DOI: 10.1021/ja01576a047
Organic Syntheses, Coll. Vol. 3, p. 475, 1955

Purification Methods

Crystallise indazole from water, sublime it in vacuo, then recrystallise it from pet ether (b 60-80o). The picrate crystallises from Et2O with m 136o. [Ainsworth Org Synth Coll Vol IV 536 1963, Beilstein 23 III/IV 1055, 23/6 V 156.]

Indazole(271-44-3)Related Product Information

• Indazole-3-carboxylic acid
• 6-Nitroindazole
• 7-Nitroindazole
• 5-Bromoindazole
• DBU
• 1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER
• Indoline
• Indole
• 11,12-Dihydroindolo[2,3-a]carbazole
• 5-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER
• 1H-INDAZOLE-5-BORONIC ACID
• Indazole-4-boronic acid, hydrochloride
• 5-Carboxyindazole hydrochloride
• 6-INDAZOLYBORONIC ACID
• 1H-INDAZOLE-5-CARBONITRILE
• 1H-INDAZOLE-4-CARBOXYLIC ACID
• 7-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-1H-INDAZOLE
• 1H-INDAZOL-7-YL BORONIC ACID