AZD-0284
AZD-0284 Basic information
- Product Name:
- AZD-0284
- Synonyms:
-
- AZD-0284
- 1H-Isoindole-1-carboxamide, 2-acetyl-2,3-dihydro-5-(methylsulfonyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-, (1R)-
- (1R)-2-acetyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-5-methanesulfonyl-2,3-dihydro-1H-isoindole-1-carboxamide
- tract,RAR-related orphan receptor,IL-17F,L-23R,Inhibitor,AZD-0284,plaque,respiratory,vulgaris,production,IL-17A,TH17,psoriasis,IL-22,AZD 0284,inhibit,cells,ROR,AZD0284
- (R)-2-Acetyl-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-5-(methylsulfonyl)isoindoline-1-carboxamide
- AZD-0284, 10 mM in DMSO
- CAS:
- 2101291-07-8
- MF:
- C21H18F6N2O5S
- MW:
- 524.43
- Mol File:
- 2101291-07-8.mol
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AZD-0284 Chemical Properties
- Boiling point:
- 731.9±60.0 °C(Predicted)
- Density
- 1.534±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 100 mg/mL (190.68 mM)
- form
- Solid
- pka
- 9.26±0.15(Predicted)
- color
- White to off-white
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AZD-0284 Usage And Synthesis
Uses
AZD-0284 is a selective inverse agonist of the nuclear receptor RORγ. AZD-0284 has the potential for plaque psoriasis vulgaris and respiratory tract disorders treatment[1].
References
[1] Narjes, F, et al. The discovery of AZD0284, an inverse agonist of the nuclear receptor RORg. American Chemical Society, 2017 Drug Design and Delivery Symposium 26 October 2017
[2] Asimus S, et al. Pharmacokinetics, pharmacodynamics and safety of the inverse retinoic acid-related orphan receptor γ agonist AZD0284 [published online ahead of print, 2020 Feb 17]. Br J Clin Pharmacol. 2020;10.1111/bcp.14253. DOI:10.1111/bcp.14253
AZD-0284Supplier
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ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
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