2-Chloro-3-methyl-5-bromopyridine Chemical Properties

Melting point:

40-44 °C

Boiling point:

78°C/3mmHg(lit.)

Density 

1.6567 (rough estimate)

refractive index 

1.5400 (estimate)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-1?+-.0.10(Predicted)

form 

Solid

color 

White to Almost white

CAS DataBase Reference

29241-60-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-37/39

HazardClass 

IRRITANT

HS Code 

29333990

MSDS

• Language:English Provider:ACROS

2-Chloro-3-methyl-5-bromopyridine Usage And Synthesis

Chemical Properties

white to light beige crystalline powder

Synthesis

Example 11B Synthesis of 5-bromo-2-chloro-3-methylpyridine: The product of Example 11A, 5-bromo-3-methylpyridin-2-one (4.1 g, 22.18 mmol), was dissolved in DMF (40 mL) and phosphoryl chloride (10 g, 65.4 mmol) was added drop-wise at 0 °C. The reaction mixture was heated at 120 °C for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and carefully poured into an ice/water mixture. The mixture was adjusted to alkaline with NH4OH, the precipitate was collected by filtration and the filter cake was washed with ice water. The resulting solid was dissolved in dichloromethane (100 mL), the organic layer was washed with brine and dried with anhydrous MgSO4. The dried solution was filtered through a silica pad and the filtrate was concentrated to give 2-chloro-3-methyl-5-bromopyridine as a white solid (3.48 g, 78% yield). The product was characterized by 1H NMR (CDCl3, 300MHz): δ 2.39 (s, 3H), 7.70 (m, 1H), 8.31 (d, J = 3Hz, 1H).

References

[1] Patent: US2002/19388, 2002, A1
[2] Patent: EP1428824, 2004, A1. Location in patent: Page 49

2-Chloro-3-methyl-5-bromopyridine(29241-60-9)Related Product Information

• Kresoxim-methyl
• 2-Chloro-3-picoline
• 3-Bromoanisole
• Methanol
• Acetonitrile
• Methyl acrylate
• Azamethiphos
• Methylparaben
• Epichlorohydrin
• Basic Violet 1
• Paraquat dichloride
• Methyl acetate
• 5-Bromo-2-methylpyridine
• 3-Bromo-2-chloropyridine
• 2,4,6-Collidine
• 2-Chloro-5-chloromethylpyridine
• 4-Methylpyridine
• 2,6-Lutidine