4'-Hydroxy-3'-methylacetophenone Chemical Properties

Melting point:

107-109 °C(lit.)

Boiling point:

175°C 1mm

Density 

1.0858 (rough estimate)

refractive index 

1.5180 (estimate)

Flash point:

175°C/1mm

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

pka

8.52±0.18(Predicted)

color 

Off-White to Pale Beige

BRN 

2041839

Stability:

Hygroscopic

LogP

1.395 (est)

CAS DataBase Reference

876-02-8(CAS DataBase Reference)

NIST Chemistry Reference

4-Hydroxy-3-methylacetophenone(876-02-8)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

36/37/39-26-22-37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29143990

MSDS

• Language:English Provider:4'-Hydroxy-3'-methylacetophenone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4'-Hydroxy-3'-methylacetophenone Usage And Synthesis

Chemical Properties

white to light beige crystalline powder or

Uses

4''-Hydroxy-3''-methylacetophenone is used in the synthesis of 3-De(hydroxymethyl)-3-methyl Salmeterol (D230650), which is an impurity of β2-Adrenergic agonist Salmeterol (S090100).

Definition

ChEBI: 4-hydroxy-3-methylacetophenone is a monohydroxyacetophenone that is acetophenone carrying methyl and hydroxy groups at positions 3 and 4, respectively. It has a role as a volatile oil component and an insect attractant. It is a monohydroxyacetophenone, a member of phenols and a hydroxytoluene. It is functionally related to an acetophenone.

Preparation

Preparation by dealkylation of 4-hydroxy-5-methyl-2-iso-propylacetophenone with aluminium chloride in chloro-benzene at 50° (53%).

Synthesis Reference(s)

Journal of Medicinal Chemistry, 23, p. 738, 1980 DOI: 10.1021/jm00181a008

4'-Hydroxy-3'-methylacetophenone(876-02-8)Related Product Information

• 4'-Hydroxyacetophenone
• 3,5-Dihydroxyacetophenone
• 3'-Methylacetophenone
• 4-Nitroacetophenone
• 2',6'-Dihydroxyacetophenone
• 4'-(Trifluoromethyl)acetophenone
• 3'-Hydroxyacetophenone
• 3-Nitroacetophenone
• 3'-(Trifluoromethyl)acetophenone
• 2-HYDROXYACETOPHENONE
• Acetophenone
• CHLOROPHOSPHONAZO III
• 2'-Hydroxyacetophenone
• 3-Methoxyacetophenone
• 4'-Methylacetophenone
• 2,4-Dihydroxyacetophenone
• PIPERACETAZINE (250 MG)
• 2',4'-Dichloroacetophenone