Basic information Safety Supplier Related

(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE

Basic information Safety Supplier Related

(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE Basic information

Product Name:
(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE
Synonyms:
  • SPIRADOLINE MESYLATE
  • U-62066
  • (+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE
  • U-62066 (mesylate)
  • rel-3,4-dichloro-N-methyl-N-[(5S,7R,8R)-7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-benzeneacetamide,monomethanesulfonate
CAS:
87173-97-5
MF:
C23H34Cl2N2O5S
MW:
521.49
Mol File:
87173-97-5.mol
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(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE Chemical Properties

storage temp. 
2-8°C
solubility 
H2O: 14 mg/mL
form 
solid
color 
white
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Safety Information

WGK Germany 
3

MSDS

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(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE Usage And Synthesis

Uses

Analgesic.

in vivo

Spiradoline mesylate (U-62066; 0.1-0.4 mg/kg; subcutaneous injection; once; Sprague-Dawley rats) treatment dose-dependently reduces social behaviors in non-stressed adults, producing social avoidance at the highest dose tested, while younger animals displays reduced sensitivity to this socially suppressing effect of Spiradoline mesylate. In stressed animals, the socially suppressing effects of the Spiradoline mesylate are blunted at all ages, with juveniles and adolescents exhibiting increased social preference in response to certain doses of U-62066[1].

Animal Model:Juvenile, adolescent and adult Sprague-Dawley male and female rats exposured to repeated restraint[1]
Dosage:0.1 mg/kg, 0.2 mg/kg, 0.3 mg/kg, and 0.4?mg/kg
Administration:Subcutaneous injection; once
Result:Dose-dependently reduced social behaviors in non-stressed adults, producing social avoidance at the highest dose tested.

(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATESupplier

Shanghai Hongye Biotechnology Co. Ltd
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Nanjing Shizhou Biology Technology Co.,Ltd
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025-85560043 15850508050
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Hebei Miaoyin Technology Co.,Ltd
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kathy@hbyinsheng.com
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(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE(87173-97-5)Related Product Information