3-Methoxypropionitrile Chemical Properties

Melting point:

-62.9 °C

Boiling point:

164-165 °C (lit.)

Density 

0.937 g/mL at 25 °C (lit.)

vapor pressure 

2.3 hPa (30 °C)

refractive index 

n20/D 1.403(lit.)

Flash point:

66 °C

storage temp. 

2-8°C

solubility 

540g/l

form 

Liquid

Specific Gravity

0.946

color 

Clear colorless to yellow

PH

6.8 (111g/l, H2O, 25℃)

explosive limit

1.9-15.3%(V)

Water Solubility 

335 g/L (20 ºC)

BRN 

1739284

CAS DataBase Reference

110-67-8(CAS DataBase Reference)

NIST Chemistry Reference

3-Methoxypropionitrile(110-67-8)

EPA Substance Registry System

Propanenitrile, 3-methoxy- (110-67-8)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

RIDADR 

3276

WGK Germany 

2

RTECS 

TZ4870000

Autoignition Temperature

390 °C DIN 51794

TSCA 

Yes

HazardClass 

3.2

PackingGroup 

III

HS Code 

29269095

Toxicity

LD50 orally in Rabbit: 4130 mg/kg LD50 dermal Rabbit > 9400 mg/kg

MSDS

• Language:English Provider:3-Methoxypropionitrile
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
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3-Methoxypropionitrile Usage And Synthesis

Chemical Properties

clear colorless to yellow liquid

Uses

3-Methoxypropionitrile is used as a component in high power lithium ion batteries. It is used as pharmaceutical intermediates. It acts as a good solvent for plastic polymers.

Synthesis

GENERAL PROCEDURE: To a solution of activated 2-acrylonitrile (0.5 mmol) in methanol (2.0 mmol) was added Na2CO3 (0.2 mL, 0.05 M aqueous solution) and the reaction mixture was stirred until the 2-acrylonitrile was either completely consumed (monitored by TLC) or a predetermined reaction time was reached. Upon completion of the reaction, the reaction mixture was extracted with ethyl acetate (3 x 5 mL). The organic layers were combined, washed with brine (10 mL), dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to give 3-methoxypropionitrile.

References

[1] Inorganic Chemistry, 2010, vol. 49, # 13, p. 6203 - 6213
[2] Tetrahedron, 2011, vol. 67, # 14, p. 2562 - 2569
[3] Tetrahedron, 1981, vol. 37, # 16, p. 2905 - 2908
[4] Tetrahedron Letters, 2014, vol. 55, # 49, p. 6718 - 6720
[5] Journal of the American Chemical Society, 2003, vol. 125, # 29, p. 8696 - 8697

3-Methoxypropionitrile(110-67-8)Related Product Information

• 2-Cyanoethyl ether
• Anisole
• p-Anisaldehyde
• (Trifluoromethoxy)benzene
• 3-Aminopropionitrile
• 3-Methoxy-1-propanol
• p-Anisidine
• Propyl cyanoacetate
• ETHYL PHENYLCYANOACETATE
• Ethyl 2-cyanopropanoate
• Methyl cyanoacetate
• Allyl cyanoacetate
• 3,3-Dimethoxypropanenitrile
• n-Butyl cyanoacetate
• Ethyl cyanoacetate
• CYCLOHEXYL CYANOACETATE
• 3-PHENOXYPROPIONITRILE
• Ethyl (ethoxymethylene)cyanoacetate