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Isazophos

Basic information Safety Supplier Related

Isazophos Basic information

Product Name:
Isazophos
Synonyms:
  • miral10g
  • o-(5-chloro-1-(1-methylethyl)-1h-1,2,4-triazol-3-yl)o,o-diethylphosphorothi
  • o-(5-chloro-1-(1-methylethyl)-1h-1,2,4-triazol-3-yl)o,o-phosphorothioicaci
  • o-(5-chloro-1-isopropyl-1h-1,2,4-triazol-3-yl)o,o-diethylphosphorothioate
  • o-5-chloro-1-isopropyl-1h-1,2,4-triazol-3-ylo,o-diethylphosphorothioate
  • O-(5-chloro-1-isopropyl-1H-1,2,4-triazol-3-yl)-O,O-diethyl phosphorothhioate
  • Phosphorothioic acid, O-5-chloro-1-(1-methylethyl)-1H-1,2,4-triazol-3-yl O,O-diethyl ester
  • isazophos (bsi,iso,ansi)
CAS:
42509-80-8
MF:
C9H17ClN3O3PS
MW:
313.74
EINECS:
255-863-8
Product Categories:
  • H-MAnalytical Standards
  • IPesticides&Metabolites
  • Alpha sort
  • Alphabetic
  • Nematicides
  • Pesticides
  • Pesticides&Metabolites
  • Analytical Standards
Mol File:
42509-80-8.mol
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Isazophos Chemical Properties

Melting point:
<25℃
Boiling point:
bp0.001 100°; bp760 170°
Density 
1.22 g/cm3 (20℃)
vapor pressure 
7.45 x 10-3 Pa (20 °C)
refractive index 
nD20 1.4867
storage temp. 
0-6°C
Water Solubility 
168 mg l-1 (20 °C)
pka
-1.47±0.10(Predicted)
form 
liquid
BRN 
8145294
EPA Substance Registry System
Isazofos (42509-80-8)
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Safety Information

Hazard Codes 
T+,N
Risk Statements 
24/25-26-43-48/20-50/53
Safety Statements 
28-36/37-38-45-59-61
RIDADR 
3018
WGK Germany 
3
RTECS 
TE7760000
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
29339900
Hazardous Substances Data
42509-80-8(Hazardous Substances Data)
Toxicity
LD50 in rats (mg/kg): 60 orally; 250-700 dermally (Dawes)
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Isazophos Usage And Synthesis

Description

Isazofos is a yellow liquid. Solubility in water is 168 mg/L (20 ?C). It is miscible with common organic solvents. Log Kow = 2.99. It is hydrolyzed in aqueous media: DT50 values (20 ?C) at pH 5, 7, and 9 are 85, 48, and 19 d, respectively.

Uses

Isazophos is an organophosphate pesticide.

Uses

Nematocide; turf insecticide.

Uses

Isazofos is used as a nematicide and soil insecticide in bananas, citrus, cotton, beet, maize, rice, vegetables, sugar cane and turf.

Definition

ChEBI: Isazofos is an organic thiophosphate.

Metabolic pathway

Isazofos is metabolised in soil to its hydrolysis product 5-chloro-1- isopropyl-3-triazolol. The oxon metabolite has apparently not been identified.

Metabolism

In mammals, administered isazofos is rapidly metabolized and excreted, primarily in the urine, without accumulation in the body. The degradation route of isazofos in soil is primarily the hydrolysis mediated by microorganisms to give 5-chloro-1-isopropyl-3-triazole. The half-life in soils is about 10 d.

Toxicity evaluation

Acute oral LD50 for rats is 40–60 mg/kg. Inhalation LC50 (4 h) for rats is about 0.24 mg/L air. NOEL (90 d) for rats is 2 mg/kg diet (0.1 mg/kg/d).

Degradation

Isazofos is hydrolysed more rapidly in alkaline rather than acid solution. The DT50 values at pH 5, 7 and 9 were 85, 48 and 19 days, respectively (PM).

Isazophos Preparation Products And Raw materials

Raw materials

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