Tofacitinib Impurity 77 Chemical Properties

Boiling point:

640.4±55.0 °C(Predicted)

Density 

1.312±0.06 g/cm3(Predicted)

storage temp. 

4°C, protect from light

pka

6.05±0.60(Predicted)

form 

Solid

color 

Light yellow to yellow

Tofacitinib Impurity 77 Usage And Synthesis

Uses

Tofacitinib metabolite-1 is a metabolite of Tofacitinib, a JAK inhibitor. Tofacitinib metabolite-1 can be used in the pharmacokinetics and metabolism studies of tofacitinib[1][2].

References

[1] Martin E Dowty, et al. The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Tofacitinib, a Janus Kinase Inhibitor, in Humans. Drug Metab Dispos. 2014 Apr;42(4):759-73. DOI:10.1124/dmd.113.054940
[2] Matthias Gehringer, et al. Novel Hinge-Binding Motifs for Janus Kinase 3 Inhibitors: A Comprehensive Structure-Activity Relationship Study on Tofacitinib Bioisosteres. ChemMedChem. 2014 Nov;9(11):2516-27. DOI:10.1002/cmdc.201402252

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