2-Chloro-3-nitro-6-methylpyridine Chemical Properties

Melting point:

70-74 °C

Boiling point:

200°C (rough estimate)

Density 

1.5610 (rough estimate)

refractive index 

1.5500 (estimate)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

soluble in Methanol

pka

-1?+-.0.10(Predicted)

form 

Powder

color 

Brown

InChI

InChI=1S/C6H5ClN2O2/c1-4-2-3-5(9(10)11)6(7)8-4/h2-3H,1H3

InChIKey

UIEVSGOVFXWCIK-UHFFFAOYSA-N

SMILES

C1(Cl)=NC(C)=CC=C1[N+]([O-])=O

CAS DataBase Reference

56057-19-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,T,Xi

Risk Statements 

36/37/38-20/21/22

Safety Statements 

36/37/39-26-36

HS Code 

29349990

MSDS

• Language:English Provider:ACROS

2-Chloro-3-nitro-6-methylpyridine Usage And Synthesis

Chemical Properties

brown powder

Uses

Iridium complexes with 2-phenylpyridine and 2-(4-dibenzofuran)pyridine as ligands are widely used organic phosphorescent materials.

Synthesis

2-Hydroxy-3-nitro-6-methylpyridine (compound 25, 10 g, 0.065 mol) was added to 50 mL of phosphoryl chloride and heated to reflux for 4 hours. Upon completion of the reaction, most of the phosphorus trichloride was removed by distillation under reduced pressure. The residue was slowly poured into 200 g of ice water and stirred for 2 hours. A large amount of precipitate appeared in the reaction mixture and the precipitate was collected by filtration under reduced pressure and dried under vacuum to give 10 g of white solid product (compound 26) in 89% yield. The melting point of the product was 68.5-70.5 °C (water) [J.O.C., 1955, 20, 1729-1731].

References

[1] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 11-12
[2] Journal of Medicinal Chemistry, 2000, vol. 43, # 22, p. 4288 - 4312
[3] Journal of the American Chemical Society, 1952, vol. 74, p. 3828,3830

2-Chloro-3-nitro-6-methylpyridine(56057-19-3)Related Product Information

• 2-Chloro-3-nitropyridine
• 4-Methylpyridine
• 6-Chloro-2-picoline
• 2,6-Lutidine
• 2-Chloro-5-chloromethylpyridine
• 4-Chloro-3-nitropyridine
• Azamethiphos
• Kresoxim-methyl
• Bensulfuron methyl
• 2,4,6-Collidine
• Methyl acrylate
• Methylparaben
• 5-Bromo-2-chloro-3-nitropyridine
• 2-Chloro-3-picoline
• 2-Chloro-4-methyl-3-nitropyridine
• Thiophanate-methyl
• 2-Chloro-5-methyl-3-nitropyridine
• Methyl