2-Chloro-4-picoline Chemical Properties

Melting point:

115°C

Boiling point:

194-195 °C (lit.)

Density 

1.142 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.529(lit.)

Flash point:

193 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

Liquid

pka

0.94±0.10(Predicted)

Specific Gravity

1.14

color 

Clear colorless to light yellow

InChI

InChI=1S/C6H6ClN/c1-5-2-3-8-6(7)4-5/h2-4H,1H3

InChIKey

MZVSTDHRRYQFGI-UHFFFAOYSA-N

SMILES

C1(Cl)=NC=CC(C)=C1

CAS DataBase Reference

3678-62-4(CAS DataBase Reference)

NIST Chemistry Reference

2-Cl-4-(CH3)-pyridine(3678-62-4)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-36-36/37/39

WGK Germany 

3

HazardClass 

IRRITANT, IRRITANT-HARMFUL

HS Code 

29349990

MSDS

• Language:English Provider:2-Chloro-4-methylpyridine
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

2-Chloro-4-picoline Usage And Synthesis

Chemical Properties

Colorless to light yellow liquid.

Uses

2-Chloro-4-methylpyridine is used as a reagent in the synthesis of the mGLUR5 modulators imidazolyl-ethynyl-pyridines as potential antipsychotics. It is also used in the preparation of trifluoromethyl(pyrimidinyl)azetidinecarboxamides as potent, orally bioavailable TGR5 agonists.

General Description

2-Chloro-4-methylpyridine (2-Chloro-4-picoline) reacts with 3,5-bis(trifluoromethyl)phenylboronic acid to form 2-(3,5-bis(trifluoromethyl)phenyl)-4-methylpyridine by palladium-catalyzed cross-coupling reaction.

2-Chloro-4-picoline(3678-62-4)Related Product Information

• 2-Chloro-5-chloromethylpyridine
• Clopidol
• 2,6-Lutidine
• Pentachloropyridine
• Epichlorohydrin
• 2-Chloro-3-cyanopyridine
• 2-Chloro-4-nitropyridine
• 2-(Chloromethyl)pyridine
• 4-Methylpyridine
• Azamethiphos
• 2,4,6-Collidine
• Chloroacetic acid
• 2-Chloro-4-(trifluoromethyl)pyridine
• 2,6-Dichloro-4-(trifluoromethyl)pyridine
• ETHYL 2-CHLORO-3-CYANO-6-METHYLISONICOTINATE
• METHYL 2,6-DICHLOROISONICOTINATE
• 2-CHLOROLEPIDINE
• 2-Chloro-4-methyl-3-nitropyridine