PHENYL N-PHENYLPHOSPHORAMIDOCHLORIDATE Chemical Properties

Melting point:

132-134 °C(lit.)

Boiling point:

366℃

Density 

1.363

Flash point:

175℃

solubility 

sol org solvents, e.g. acetone, dichloromethane.

form 

solid

color 

white

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29310099

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

PHENYL N-PHENYLPHOSPHORAMIDOCHLORIDATE Usage And Synthesis

Chemical Properties

white powder

Uses

Phenyl N-Phenylphosphoramidochloridate is a phosphorylating agent in oligonucleotide synthesis via the phosphotriester approach; for the conversion of acids to their symmetrical anhydrides and for the coupling of acids and amines to give amides; two important derivatives are also considered.

Preparation

Phenyl N-Phenylphosphoramidochloridate is obtained from phenyl phosphorodichloridate (2) and aniline (eq 1).^[1]

storage

Phenyl N-Phenylphosphoramidochloridate is irritating and moisture-sensitive. It may be harmful by inhalation (irritating to mucous membranes and upper respiratory tract), ingestion, or skin absorption. Incompatible with strong oxidizing agents and strong bases.

References

1. Cremlyn, R. W. J.; Kishore, D. N. JCS(P1) 1972, 585.

PHENYL N-PHENYLPHOSPHORAMIDOCHLORIDATE(51766-21-3)Related Product Information

• 2-CHLOROPHENYL(4-METHOXYPHENYL) PHOSPHORAMIDOCHLORIDATE
• 2-CHLOROPHENYL-N-PHENYL-CHLOROPHOSPHORAMIDATE
• PHENYL N-PHENYLPHOSPHORAMIDOCHLORIDATE
• 4-CHLOROPHENYL PHENYLPHOSPHORAMIDOCHLORIDATE