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Crisaborole Impurity

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Crisaborole Impurity Basic information

Product Name:
Crisaborole Impurity
Synonyms:
  • 3-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]Benzonitrile
  • Crisaborole intermediate
  • 5-(4-cyanophenoxy)-2-hydroxybenzoic acid
  • 4-(3-formyl-4-hydroxyphenoxy)benzonitrile
  • 4-((2,2'-diformyl-4'-(4-isocyanophenoxy)-[1,1'-biphenyl]-4-yl)oxy)benzonitrile
  • 4-(3-formyl-4-(3-formyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)phenoxy)benzonitrile
  • 4-(3-(hydroxymethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)benzonitrile
  • 4-(2-bromo-5-(hydroxymethyl)phenoxy)benzonitrile
CAS:
906673-42-5
MF:
C14H10BNO3
MW:
251.05
Product Categories:
  • GYL
Mol File:
906673-42-5.mol
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Crisaborole Impurity Chemical Properties

Melting point:
180-183°C
Boiling point:
411.1±55.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly)
pka
7.04±0.20(Predicted)
form 
Solid
color 
White to Off-White
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Crisaborole Impurity Usage And Synthesis

Uses

5-(4-Cyanophenoxy)-2-hydroxybenzoic Acid is an impurity of Crisaborole(H947928). Crisaborole exhibits inhibitory activity against PDE4 and cytokine release.

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