ELA-14 (human) Chemical Properties

form 

Solid

color 

White to off-white

Sequence

{Glp}-Arg-Arg-Cys-Met-Pro-Leu-His-Ser-Arg-Val-Pro-Phe-Pro

ELA-14 (human) Usage And Synthesis

Uses

Elabela(19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1].

in vivo

References

[1] Alexandre Murza, et al. Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA That Modulates Vascular and Cardiac Functions. J Med Chem. 2016 Apr 14;59(7):2962-72. DOI:10.1021/acs.jmedchem.5b01549

ELA-14 (human)(1886973-05-2)Related Product Information

• H-LEU-PRO-ARG-LEU-LEU-HIS-THR-ASP-SER-ARG-MET-ALA-THR-ILE-ASP-PHE-PRO-LYS-LYS-ASP-PRO-THR-THR-SER-LEU-GLY-ARG-PRO-PHE-PHE-LEU-PHE-ARG-PRO-ARG-ASN-NH2
• [NPHE1]NOCICEPTIN(1-13)NH2
• Cenupatide
• Met-enkephalinamide
• GLY-SER-SER-PHE-LEU-SER-PRO-GLU-HIS-GLN-LYS-ALA-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG
• RRKDLHDDEEDEAMSITA
• GIP (HUMAN)
• ASN-GLU-ALA-TYR-VAL-HIS-ASP-ALA-PRO-VAL-ARG-SER-LEU-ASN