FUMITREMORGIN C Chemical Properties

Melting point:

259.5-260.5℃

Boiling point:

642.9±55.0 °C(Predicted)

Density 

1.34±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

acetonitrile: 5 mg/mL, soluble

form 

solid

pka

17.16±0.40(Predicted)

color 

White to light brown

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

HS Code 

2941900000

FUMITREMORGIN C Usage And Synthesis

Uses

Fumitremorgin C is a tremorgenic mycotoxin isolated from Aspergillus fumigatus. Recent research has determined fumitremorgin C as a potent inhibitor of the breast cancer resistance protein BCRP/ABCG2 multidrug transporter.

Definition

ChEBI: An organic heteropentacyclic compound that is a mycotoxic indole alkaloid produced by several fungi. A potent and specific inhibitor of the breast cancer resistance protein multidrug transporter.

General Description

A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) multidrug transport activity. Also acts as a potent and specific chemosenzitizing agent.

Biochem/physiol Actions

Cell permeable: yes

target

Antifection | P-gp

storage

+4°C

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