GO 6983
GO 6983 Basic information
- Product Name:
- GO 6983
- Synonyms:
-
- G 6983 - GO 6983 | Goe 6983
- CS-674
- G 6983 - CAS 133053-19-7 - Calbiochem
- GO6983 GO-6983
- GOE 6983;GO6983 GO-6983;GO 6983
- gǒ 6983
- GOE 6983
- Gδ 6983
- CAS:
- 133053-19-7
- MF:
- C26H26N4O3
- MW:
- 442.51
- Product Categories:
-
- Smad
- TGF-beta
- TGF-beta/Smad
- Inhibitors
- Mol File:
- 133053-19-7.mol
GO 6983 Chemical Properties
- Boiling point:
- 709.0±60.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: 20 mg/mL, clear, red
- form
- powder
- pka
- 8.02±0.60(Predicted)
- color
- red
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
GO 6983 Usage And Synthesis
Description
Go-6983 (133053-19-7) potent and pan-specific, ATP-competitive protein kinase C inhibitor. PKC isotype IC50s= 7, 7, 6, 10 and 60 nM for PKC α, β, γ, δ, ζ respectively.1 Suppresses stress induced HSP27 disassociation.2 Maintains rat embryonic stem cell pluripotency.3 Attenuates myocardial ischemia/reperfusion injury.4
Uses
Go 6983, is a protein kinase C (PKC) inhibitor.Potent PKC Inhibitor
Uses
GO6983 has been used as a protein kinase C (PKC) inhibitor to study its effects on the nuclear import. It has also been used as a supplement in Fc medium to culture mouse embryonic stem (mES) cells on mitomycin C treated mouse embryonic fibroblasts (MEFs).
Definition
ChEBI: 3-[1-[3-(dimethylamino)propyl]-5-methoxy-3-indolyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione is a member of indoles and a member of maleimides.
Biological Activity
Broad spectrum protein kinase C (PKC) inhibitor (IC 50 values are 7, 7, 6, 10, 60 and 20000 nM for PKC α , PKC β , PKC γ , PKC δ , PKC ζ and PKC μ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.
Biochem/physiol Actions
Protein kinase C (PKC) inhibitor that selectively inhibits several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ), but does not inhibit PKCμ (IC50 = 20 mM).
storage
-20°C
References
1) Gschwendt et al. (1996), Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase C isoenzymes; FEBS Lett., 392 77 2) Kato et al. (2001), Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27; Cell Stress Chaperones, 6 16 3) Rajendran et al. (2013), Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency; J. Biol. Chem., 288 24351 4) Young et al. (2005), Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury; Cardiovasc, Drug Rev., 23 255
GO 6983Supplier
- Tel
- sales@boylechem.com
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
- Tel
- +86 (531) 88811783
- sales@trio-pharmatech.com (International market)
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
GO 6983(133053-19-7)Related Product Information
- D-ERYTHRO-SPHINGOSINE
- Sotrastaurin
- Y27632 (hydrochloride)
- 1,9-Pyrazoloanthrone
- GO 6976
- CHIR-99021
- Olaparib
- GF109203X
- GANGLIOSIDE GD1A DISODIUM SALT
- BISINDOLYLMALEIMIDE II
- BISINDOLYLMALEIMIDE VII
- 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether
- 5-HYDROXYINDOLE-3-ACETAMIDE
- 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione
- N-PROPIONYL-5-METHOXYTRYPTAMINE
- GO 6983
- 2-(5-METHOXY-1H-INDOL-3-YL)-ACETAMIDE
- [1-(3-DIMETHYLAMINO-PROPYL)INDOL-3-YL]ACETAMIDE