6-FLUORO-2-METHYLINDOLE Chemical Properties

Melting point:

100

Boiling point:

269℃

Density 

1.219

Flash point:

117℃

storage temp. 

Sealed in dry,Room Temperature

pka

16.97±0.30(Predicted)

Appearance

White to yellow Solid

InChI

InChI=1S/C9H8FN/c1-6-4-7-2-3-8(10)5-9(7)11-6/h2-5,11H,1H3

InChIKey

DQDVUUGKFGUZCF-UHFFFAOYSA-N

SMILES

N1C2=C(C=CC(F)=C2)C=C1C

Safety Information

Hazard Codes 

Xi

Hazard Note 

Irritant

HS Code 

2933998090

6-FLUORO-2-METHYLINDOLE Usage And Synthesis

Synthesis

Example 5: Synthesis of 6-fluoro-2-methylindole In a 100 mL stainless steel autoclave, 1.0 g (5.1 mmol) of 1-(4-fluoro-2-nitrophenyl)propan-2-one, 130 mg (4 mol%) of triruthenium tricarbonyl, 397 mg of 2,2'-bipyridine and 40 g of toluene were added and the system was reacted under nitrogen protection under the same conditions as in Example 4. After completion of the reaction, the reaction solution was quantitatively analyzed by high performance liquid chromatography (HPLC). The analytical results showed 100% conversion of 1-(4-fluoro-2-nitrophenyl)propan-2-one and gave 0.65 g (97.0% yield) of 6-fluoro-2-methylindole.

References

[1] Patent: US2007/83053, 2007, A1. Location in patent: Page/Page column 7
[2] Patent: US2007/83053, 2007, A1. Location in patent: Page/Page column 6
[3] Patent: US2007/83053, 2007, A1. Location in patent: Page/Page column 6
[4] Patent: US2007/83053, 2007, A1. Location in patent: Page/Page column 6
[5] Organic and Biomolecular Chemistry, 2016, vol. 14, # 44, p. 10511 - 10515

6-FLUORO-2-METHYLINDOLE(40311-13-5)Related Product Information

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