Basic information Safety Supplier Related

CD437

Basic information Safety Supplier Related

CD437 Basic information

Product Name:
CD437
Synonyms:
  • 2-naphthalenecarboxylicacid,6-(4-hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphen
  • 6-(4-hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphenyl)-2-naphthalenecarboxylic
  • AHPN, 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid
  • O-DesMethyl Adapalene
  • CD 437/AHPN
  • Adapalene IMpurity F
  • Apoptosis Activator VI, CD437/AHPN
  • ADAP-IME
CAS:
125316-60-1
MF:
C27H26O3
MW:
398.49
EINECS:
200-258-5
Product Categories:
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
125316-60-1.mol
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CD437 Chemical Properties

Melting point:
271.6-276 °C
Boiling point:
595.0±50.0 °C(Predicted)
Density 
1.290
storage temp. 
-20°C
solubility 
DMSO: 26 mg/mL
form 
solid
pka
4.17±0.30(Predicted)
color 
yellow
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Safety Information

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
QJ1975900
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CD437 Usage And Synthesis

Chemical Properties

Yellow Solid

Uses

An intermediate in the preparation of Adapalene derivatives.

Definition

ChEBI: A naphthoic acid that is 6-phenylnaphthylene-2-carboxyic acid in which the phenyl substituent has been substituted at positions 3 and 4 by adamant-1-yl and hydroxy groups, respectively. It acts as a selective agonist of retinoic acid receptor (RAR)g mma and induces cell cycle arrest and apoptosis in various cancer cells.

Biological Activity

Synthetic retinoid that is an RAR γ -selective agonist. Displays RAR γ -dependent and -independent effects on differentiation and apoptosis.

Biochem/physiol Actions

CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis.

storage

Store at -20°C

CD437Supplier

Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Email
sales@boylechem.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Email
chenyj@titansci.com
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com