CD437
CD437 Basic information
- Product Name:
- CD437
- Synonyms:
-
- 2-naphthalenecarboxylicacid,6-(4-hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphen
- 6-(4-hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphenyl)-2-naphthalenecarboxylic
- AHPN, 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid
- O-DesMethyl Adapalene
- CD 437/AHPN
- Adapalene IMpurity F
- Apoptosis Activator VI, CD437/AHPN
- ADAP-IME
- CAS:
- 125316-60-1
- MF:
- C27H26O3
- MW:
- 398.49
- EINECS:
- 200-258-5
- Product Categories:
-
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 125316-60-1.mol
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CD437 Chemical Properties
- Melting point:
- 271.6-276 °C
- Boiling point:
- 595.0±50.0 °C(Predicted)
- Density
- 1.290
- storage temp.
- -20°C
- solubility
- DMSO: 26 mg/mL
- form
- solid
- pka
- 4.17±0.30(Predicted)
- color
- yellow
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Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- RTECS
- QJ1975900
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CD437 Usage And Synthesis
Chemical Properties
Yellow Solid
Uses
An intermediate in the preparation of Adapalene derivatives.
Definition
ChEBI: A naphthoic acid that is 6-phenylnaphthylene-2-carboxyic acid in which the phenyl substituent has been substituted at positions 3 and 4 by adamant-1-yl and hydroxy groups, respectively. It acts as a selective agonist of retinoic acid receptor (RAR)g mma and induces cell cycle arrest and apoptosis in various cancer cells.
Biological Activity
Synthetic retinoid that is an RAR γ -selective agonist. Displays RAR γ -dependent and -independent effects on differentiation and apoptosis.
Biochem/physiol Actions
CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis.
storage
Store at -20°C
CD437Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- 021-50182298 021-50180596
- sales@boylechem.com
J & K SCIENTIFIC LTD.
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
Adamas Reagent, Ltd.
- Tel
- 400-6009262 16621234537
- zhangsn@titansci.com
Chemsky（shanghai）International Co.,Ltd.
- Tel
- 021-50135380
- shchemsky@sina.com
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CD437(125316-60-1)Related Product Information
- 2,2'-Bis-(1-adaMantyl)-4,4'-diMethoxybiphenyl
- Methyl 6-bromo-2-naphthoate
- o-AdaMantylanisole
- 1-Adamantanol
- 1-NITROADAMANTANE
- N,N-Dimethyl-1-adamantylamine
- Adapalene
- Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate
- O-DESMETHYLCARVEDILOL
- Phenol, 4-(2-(4-((1-((4-fluorophenyl)methyl)-1H-benzimidazol-2-yl)amin o)-1-piperidinyl)ethyl)-
- O-desmethylangolensin
- 1-(4-Hydroxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
- N-(3-bromo-4-oxocyclohexyl)acetamide
- O-Desmethyl Apremilast Glucuronide Sodium Salt
- O-Desmethyl-Asoprisnil
- O-Desmethyl-Asoprisnil-d4
- 2-(1-ADAMANTYL)-4-METHYLPHENOL
- CD437