R-(+)-DIOA
R-(+)-DIOA Basic information
- Product Name:
- R-(+)-DIOA
- Synonyms:
-
- R(+)-Butylindazone, R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid
- Acetic acid, 2-[[(2R)-2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl]oxy]-
- CAS:
- 81166-47-4
- MF:
- C20H24Cl2O4
- MW:
- 399.31
- Mol File:
- 81166-47-4.mol
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R-(+)-DIOA Chemical Properties
- Melting point:
- 173-174 °C
- Boiling point:
- 562.2±50.0 °C(Predicted)
- Density
- 1.307±0.06 g/cm3(Predicted)
- solubility
- H2O: insoluble <0.11mg/mL
- form
- solid
- pka
- 2.80±0.10(Predicted)
- color
- white
- optical activity
- [α]27/D +18.1°, c = 0.7 in methanol(lit.)
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R-(+)-DIOA Usage And Synthesis
Uses
R-(+)-DIOA is an inhibitor of the K+/Cl--cotransport that does not affect the bumetanide-Na+/K+/Cl--cotransport system.
Uses
R-(+)-DIOA has been used as a potassium/chloride K+-Cl- transport inhibitor to study its effects on:
- short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium
- uptake of grepafloxacin by THP-1 monocytes
- the uptake of moxifloxacin by THP-1 monocytes
Biochem/physiol Actions
[(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K+–Cl?)?co-transporter. It does not exert its effects on bumetanimide-sensitive [Na+,K+,Cl-]-cotransport system.
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R-(+)-DIOA(81166-47-4)Related Product Information
- 3-CHLORO-5-METHYLPHENOL
- 5-METHOXYINDAN
- 2-PROPYL-1-INDANONE, 98
- 3-METHYLPHENOXYACETIC ACID
- 3-CHLORO-4-METHOXYACETOPHENONE
- 2-CHLORO-5-METHYLPHENOL
- 3-Chlorophenoxyacetic acid
- 2,3-Dichlorophenol
- 4'-Hydroxyvalerophenone
- 2,3-DICHLOROANISOLE
- 3'-Chloropropiophenone
- 2-Chloro-4-hydroxybenzaldehyde
- 2,3-Dichloroacetophenone
- 3,4-DIMETHYLPHENOXYACETIC ACID
- 2-METHYL-1-INDANONE
- 5-Methoxy-1-indanone
- 2,3-DIHYDRO-2,2-DIMETHYLINDEN-1-ONE
- 2-(3-CHLOROPHENOXY)ETHANOL