R-(+)-DIOA Chemical Properties

Melting point:

173-174 °C

Boiling point:

562.2±50.0 °C(Predicted)

Density 

1.307±0.06 g/cm3(Predicted)

solubility 

H2O: insoluble <0.11mg/mL

form 

solid

pka

2.80±0.10(Predicted)

color 

white

optical activity

[α]27/D +18.1°, c = 0.7 in methanol(lit.)

Safety Information

WGK Germany 

3

R-(+)-DIOA Usage And Synthesis

Uses

R-(+)-DIOA is an inhibitor of the K+/Cl--cotransport that does not affect the bumetanide-Na+/K+/Cl--cotransport system.

Uses

R-(+)-DIOA has been used as a potassium/chloride K⁺-Cl^- transport inhibitor to study its effects on:

• short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium
• uptake of grepafloxacin by THP-1 monocytes
• the uptake of moxifloxacin by THP-1 monocytes

Biochem/physiol Actions

[(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K+–Cl?)?co-transporter. It does not exert its effects on bumetanimide-sensitive [Na+,K+,Cl-]-cotransport system.

R-(+)-DIOA(81166-47-4)Related Product Information

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