4-Bromo-2,6-dichlorophenol Chemical Properties

Melting point:

64-65℃

Boiling point:

247℃

Density 

1.890

Flash point:

103℃

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

Powder

pka

6.46±0.23(Predicted)

color 

Off-white

Safety Information

HazardClass 

IRRITANT

HazardClass 

6.1

HS Code 

2908190090

4-Bromo-2,6-dichlorophenol Usage And Synthesis

Chemical Properties

White or slightly pink crystals. Melting point 66.5°C. Soluble in alcohol and ether, slightly soluble in cold petroleum ether, insoluble in water.

Synthesis

Obtained by bromination and chlorination of o-chlorophenol: dissolve o-chlorophenol in carbon tetrachloride, add bromine dropwise with stirring at below 30°C, continue stirring and react for 2h after addition, then remove hydrobromic acid at room temperature, recover carbon tetrachloride and distill under reduced pressure, collect the fraction of 110-120°C (2kPChemicalbooka), and obtain 4-bromo-2-chlorophenol. Dissolve 4-bromo-2-chlorophenol in acetic acid and pass chlorine gas under ice-cold conditions until no more crystals are precipitated. Heat and reflux until all crystals are dissolved, decolorized, filtered, cool and crystallized, filter, and wash with petroleum ether to obtain the finished product 4-Bromo-2,6-dichlorophenol.

References

[1] Patent: WO2007/134864, 2007, A1. Location in patent: Page/Page column 32
[2] Chinese Chemical Letters, 2012, vol. 23, # 4, p. 387 - 390
[3] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 4, p. 884 - 886
[4] Journal of the Iranian Chemical Society, 2012, vol. 9, # 3, p. 321 - 326
[5] Patent: US2013/131016, 2013, A1. Location in patent: Paragraph 0294; 0295

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