2-HYDROXY-4-NITRO-BENZALDEHYDE Chemical Properties

Melting point:

128-130°C

Boiling point:

309.2±32.0 °C(Predicted)

Density 

1.500±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform, Dichloromethane, Methanol,

form 

Solid

pka

6.37±0.19(Predicted)

color 

Yellow Crystalline

Safety Information

Risk Statements 

43

Safety Statements 

36/37

HS Code 

2913000090

2-HYDROXY-4-NITRO-BENZALDEHYDE Usage And Synthesis

Chemical Properties

Yellow Crystalline Solid

Uses

2-Hydroxy-4-nitrobenzaldehyde (cas# 2460-58-4) is a compound useful in organic synthesis.

Synthesis

2-(Hydroxymethyl)-5-nitrophenol (13 g, 77 mmol) was mixed with manganese dioxide (26.7 g, 308 mmol) in ethyl acetate (250 mL). The reaction mixture was heated to 80 °C and the reaction was stirred at this temperature for 16 hours. After completion of the reaction, insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography with the eluent of petroleum ether/ethyl acetate (1:3, v/v) to give 2-hydroxy-4-nitrobenzaldehyde (10.5 g) in 81.7% yield.

References

[1] Journal of the Iranian Chemical Society, 2017, vol. 14, # 9, p. 1917 - 1933
[2] Synlett, 2003, # 12, p. 1868 - 1870
[3] Journal of the American Chemical Society,
[4] Journal of the American Chemical Society, 2009, vol. 131, p. 1187 - 1194
[5] Patent: CN106349233, 2017, A. Location in patent: Paragraph 0119; 0123; 0124; 0125

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