GPAT4 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human

Background

Glycerol-3-phosphate acyltransferases catalyze the first step in the de novo synthesis of triacylglycerol and phospholipids by converting glycerol-3-phosphate to lysophosphatidic acid. The GPAT family consists of four family members: two mitochondrial proteins and two microsomal proteins. Each can differ in tissue expression, regulation, and physiological and pathophysiological roles. The microsomal proteins GPAT3 and GPAT4 were originally designated as AGPAT8 and AGPAT6, respectively. 1-acyl-glycerol-3-phosphate acyltransferase catalyzes the subsequent reaction converting LPA to phosphatidic acid. The genes were renamed to GPAT3 and GPAT4 upon elucidation of GPAT activity. Both GPAT3 and GPAT4 are expressed in adipose tissue, but GPAT3 is highly induced during adipocyte differentiation. Brown adipose tissue preferentially expresses GPAT4. GPAT3 and GPAT4 may also be phosphorylated in response to insulin treatment to increase GPAT activity. Accumulation of saturated LPA produced by GPAT4 at the ER-mitochondrial contact site can inhibit autophagy through the abnormal formation of omegasomes, which are precursors to the autophagosome. Glycerolipid synthesis by GPAT3 and GPAT4 can also regulate activation of macrophages.

References

[1] Yamashita, A. et al. (2014) Biology (Basel) 3, 801-30.
[2] Karasawa, K. et al. (2019) Int J Mol Sci 20, 964. doi: 10.3390/ijms20040964.
[3] Chen, Y.Q. et al. (2008) J Biol Chem 283, 10048-57.
[4] Cao, J. et al. (2006) Proc Natl Acad Sci U S A 103, 19695-700.
[5] Cooper, D.E. et al. (2015) J Biol Chem 290, 15112-20.
[6] Shan, D. et al. (2010) J Lipid Res 51, 1971-81.
[7] Shiozaki, Y. et al. (2020) iScience 23, 101105.
[8] Quiroga, I.Y. et al. (2019) Biochem J 476, 85-99.

GPAT4 antibody()Related Product Information

• Rabbit Polyclonal WNK2 Antibody
• RARG antibody
• XPNPEP3 antibody
• SLC7A11 antibody
• anti- PSMC4 antibody
• UCP1 antibody
• anti- PLEKHA1 antibody
• PSMA1 antibody
• XKRX Antibody
• TGM1 antibody