HCV NS5a Usage And Synthesis

Description

Recombinant HCV NS5A produced in E. coli is a single polypeptide chain containing 118 amino acids (aa 2210-2306) and having a molecular mass of 13.4kDa.
Recombinant HCV NS5A is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli

Background

NS5A is a component of the replication complex which takes part in RNA-binding. NS5A protein’s hyperphosphorylated form is an inhibitor of viral replication. NS5A interacts with Human VAPB and through it targets the viral replication complex to vesicles. NS5A down-regulates viral IRES translation initiation and mediates interferon resistance by interacting and inhibiting human EIF2AK2/PKR. NS5a is also inhibits apoptosis by interacting with BIN1 and FKBP8.

HCV NS5a()Related Product Information

• SW 1417
• MLE-12
• RMC-1
• HCV NS5b
• HCV-NS4a
• SUPB15
• KBM-7
• HCC2279
• Bone Marrow Mesenchymal Stem Cells
• HCV-NS3
• Htori-3
• OCI-Ly18
• HCV E2
• Walker256
• M-NFS-60 mouse myeloid leukemia cells
• NA
• NA
• TREGS mouse regulatory T cells