TAT-GluA2 3Y
TAT-GluA2 3Y Basic information
- Product Name:
- TAT-GluA2 3Y
- Synonyms:
-
- TAT-GluA2 3Y
- Glycine, L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-tyrosyl-L-lysyl-L-α-glutamylglycyl-L-tyrosyl-L-asparaginyl-L-valyl-L-tyrosyl-
- TAT-GluA2 3Y TFA
- CAS:
- 1404188-93-7
- MF:
- C115H185N43O29
- MW:
- 2634.02
- Mol File:
- 1404188-93-7.mol
TAT-GluA2 3Y Chemical Properties
- Density
- 1.52±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to off-white
TAT-GluA2 3Y Usage And Synthesis
Uses
TAT-GluA2 3Y, an interference peptide, blocks long-term depression (LTD) at glutamatergic synapses by disrupting the endocytosis of AMPAR. TAT-GluA2 3Y can alleviate Pentobarbital-induced spatial memory deficits and synaptic depression[1][2][3].
References
[1] Choi FY, et, al. Interference with AMPA receptor endocytosis: effects on behavioural and neurochemical correlates of amphetamine sensitization in male rats. J Psychiatry Neurosci. 2014 May;39(3):189-99. DOI:10.1503/jpn.120257
[2] Chen Z, et, al. Prolonged adenosine A1 receptor activation in hypoxia and pial vessel disruption focal cortical ischemia facilitates clathrin-mediated AMPA receptor endocytosis and long-lasting synaptic inhibition in rat hippocampal CA3-CA1 synapses: differential regulation of GluA2 and GluA1 subunits by p38 MAPK and JNK. J Neurosci. 2014 Jul 16;34(29):9621-43. DOI:10.1523/JNEUROSCI.3991-13.2014
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