BEZAFIBRATE-D4 Chemical Properties

Melting point:

181-184°C

storage temp. 

Hygroscopic, -20°C Freezer, Under Inert Atmosphere

solubility 

Acetone, DMSO (Slightly), Methanol

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

BEZAFIBRATE-D4 Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

Bezafibrate-d4 is deuterium labeled Bezafibrate. Bezafibrate is an agonist of PPAR, with EC50s of 50 μM, 60 μM, 20 μM for human PPARα, PPARγ and PPARδ, and 90 μM, 55 μM, 110 μM for murine PPARα, PPARγ and PPARδ, respectively; Bezafibrate is used as an hypolipidemic agent.

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Willson TM, et al. The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000 Feb 24;43(4):527-50. DOI:10.1021/jm990554g
[3] Usui-Ouchi A, et al. The peroxisome proliferator-activated receptor pan-agonist bezafibrate suppresses microvascular inflammatory responses of retinal endothelial cells and vascular endothelial growth factor production in retinal pigmented epithelial cells. Int Immunopharmacol. 2017 Nov;52:70-76. DOI:10.1016/j.intimp.2017.08.027
[4] Franko A, et al. Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice. Mol Metab. 2017 Jan 6;6(3):256-266. DOI:10.1016/j.molmet.2016.12.007

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