tert-Butyl 3-aminopyrrolidine-1-carboxylate Chemical Properties

Boiling point:

257.4±33.0 °C(Predicted)

Density 

1.022

Flash point:

91°C

refractive index 

1.4710

storage temp. 

2-8°C

pka

9.55±0.20(Predicted)

form 

powder to lump to clear liquid

color 

White or Colorless to Light yellow

Sensitive 

Air Sensitive

CAS DataBase Reference

186550-13-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,Xi,Xn

Risk Statements 

36/37/38-44-41-22

Safety Statements 

26-36/37/39

RIDADR 

2810

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

8

PackingGroup 

Ⅲ

HS Code 

29339900

tert-Butyl 3-aminopyrrolidine-1-carboxylate Usage And Synthesis

Chemical Properties

Colorless low melting solid or liquid

Uses

1-Boc-3-Aminopyrrolidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis

Step (ii): preparation of tert-butyl 3-aminopyrrolidine-1-carboxylate (Formula 49) To a stirred solution of tert-butyl 3-hydroxypyrrolidine-1-carboxylate (Formula 48, 1.15 g, 4.16 mmol) in methanol (16.6 mL) was added 10% palladium/carbon catalyst (345 mg). The reaction mixture was stirred for 16 hours under a hydrogen atmosphere (hydrogen pressure applied via a double-layer balloon). Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad to remove the catalyst and the filtrate was concentrated under reduced pressure. The crude product was purified by silica gel fast column chromatography to afford the target compound tert-butyl 3-aminopyrrolidine-1-carboxylate (Formula 49, 640 mg) in 82% yield. 1H-NMR (CDCl3): δ 3.65-3.45 (m, 3H), 3.45-3.33 (m, 1H), 3.20-3.0 (m, 1H), 2.12-2.02 (m, 1H), 1.80-1.65 (m, 1H), 1.46 (s, 9H). Mass spectrum (m/z): 187 [M+H]+.

References

[1] Patent: WO2005/77924, 2005, A1. Location in patent: Page/Page column 76
[2] Patent: WO2011/30349, 2011, A1. Location in patent: Page/Page column 36-37

tert-Butyl 3-aminopyrrolidine-1-carboxylate(186550-13-0)Related Product Information

• Crospovidone
• Butyl acetate
• Povidone iodine
• Dibutyl phthalate
• Cyhalofop-butyl
• 3-Aminopyrrolidine
• Diethylene glycol monobutyl ether
• BUTYL OLEATE
• Buprofezin
• RESMETHRIN
• Polyvinylpyrrolidone
• N-Methyl-2-pyrrolidone
• N-Vinyl-2-pyrrolidone
• tert-butyl 3-bromoazetidine-1-carboxylate
• METHYL-2-PYRROLIDONE
• N-Boc-cis-4-Fmoc-Amino-L-proline
• N-Boc-trans-4-amino-L-proline methyl ester hydrochloride
• (2S,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate hydrochloride