ChemicalBook > Product Catalog > Chemical Reagents > Organic reagents > Silane > N-(Trimethylsilyl)acetamide
N-(Trimethylsilyl)acetamide
N-(Trimethylsilyl)acetamide Basic information
- Product Name:
- N-(Trimethylsilyl)acetamide
- Synonyms:
-
- N-(TRIMETHYLSILYL)ACETAMIDE FOR SYNTHESI
- N-(Trimethylsilyl)acetamide,97%
- N-(Trimethylsilyl)
- (acetylamino)trimethylsilane
- n-(trimethylsilyl)-acetamid
- N-TRIMETHYLSILYLACETAMIDE
- TRIMETHYLSILYLACETAMIDE
- TMSA
- CAS:
- 13435-12-6
- MF:
- C5H13NOSi
- MW:
- 131.25
- EINECS:
- 236-565-7
- Product Categories:
-
- Aliphatics
- Miscellaneous Reagents
- Analytical Chemistry
- GC Derivatizing Reagents
- Si (Classes of Silicon Compounds)
- Silicon Compounds (for Synthesis)
- Silylacetamides
- Silylation (GC Derivatizing Reagents)
- Si-N Compounds
- Synthetic Organic Chemistry
- Trimethylsilylation (GC Derivatizing Reagents)
- Mol File:
- 13435-12-6.mol
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N-(Trimethylsilyl)acetamide Chemical Properties
- Melting point:
- 46-49 °C(lit.)
- Boiling point:
- 84 °C18 mm Hg(lit.)
- Density
- 0.859±0.06 g/cm3(Predicted)
- Flash point:
- 135 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform, DMSO, Methanol
- form
- Crystalline Mass
- pka
- 18.23±0.46(Predicted)
- color
- White to yellow
- Water Solubility
- reacts
- Hydrolytic Sensitivity
- 7: reacts slowly with moisture/water
- Sensitive
- Moisture Sensitive
- BRN
- 741928
- Stability:
- Moisture Sensitive
- CAS DataBase Reference
- 13435-12-6(CAS DataBase Reference)
- EPA Substance Registry System
- Acetamide, N-(trimethylsilyl)- (13435-12-6)
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Safety Information
- Hazard Codes
- Xi-F,Xi,F
- Risk Statements
- 36/37/38-11
- Safety Statements
- 37/39-26
- RIDADR
- 1325
- WGK Germany
- 3
- RTECS
- AD0250000
- F
- 10-21
- TSCA
- Yes
- HazardClass
- 4.1
- PackingGroup
- III
- HS Code
- 29319090
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
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N-(Trimethylsilyl)acetamide Usage And Synthesis
Chemical Properties
WHITE TO YELLOWISH CRYSTALLINE MASS
Uses
N-Trimethylsilylacetamide is a silylating agent used in organic synthesis. N-Trimethylsilylacetamide is used in the preparation of the antibacterial agent Cefdinir (C242670).
General Description
The efficiency of N-(Trimethylsilyl)acetamide (TMS acetamide) as allyl group scavenger and its compatibility with Fluorenylmethyloxycarbonyl chloride (Fmoc) protecting groups were studied.
Purification Methods
Distil the amide repeatedly in an inert atmosphere with all operations to be performed in an anhydrous atmosphere. In the presence of moisture, trimethylsilanol (b 31-34o/26mm) is formed and is a likely impurity (check by NMR). [Birkofer et al. Chem Ber 96 1473 1963, Beilstein 4 IV 4011.]
N-(Trimethylsilyl)acetamideSupplier
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N-(Trimethylsilyl)acetamide(13435-12-6)Related Product Information
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- Silicone rubber,methyl-vinyl
- N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide
- BIS(TRIMETHYLSILYL)HYPOXATHINE
- N-METHYL-N-TRIMETHYLSILYLHEPTAFLUOROBUTYRAMIDE
- N-Methyl-N-(trimethylsilyl)acetamide
- N-Methyl-N-(trimethylsilyl)trifluoroacetamide
- N-(TERT-BUTYLDIMETHYLSILYL)PHTHALIMIDE
- N,N-Bis(trimethylsilyl)acetamide
- (4S)-N-(TERT-BUTYLDIMETHYLSILYL)AZETIDIN-2-ONE-4-CARBOXYLIC ACID
- (4R)-N-(TERT-BUTYLDIMETHYLSILYL)AZETIDIN-2-ONE-4-CARBOXYLIC ACID
- (5-METHYL-1,3-BIS-TRIMETHYLSILYL)-2,4-(1H,3H-PYRIMIDINEDIONE)
- METHACRYLAMIDOTRIMETHYLSILANE