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Bis(2-chloroethyl)amine hydrochloride

Basic information Safety Supplier Related

Bis(2-chloroethyl)amine hydrochloride Basic information

Product Name:
Bis(2-chloroethyl)amine hydrochloride
Synonyms:
  • BIS (2-CHLOROETHYL) AMINE HCL
  • BIS(2-CHLOROETHYL)AMINE HYDROCHLORIDE
  • BIS(2-CHLOROETHYL)AMMONIUM CHLORIDE
  • DI-(2-CHLOROETHYL)AMINE HYDROCHLORIDE
  • 2,2'-DICHLORODIETHYLAMINE HYDROCHLORIDE
  • 2,2’-dichloro-diethylaminhydrochloride
  • 2-chloro-n-(2-chloroethyl)ethanaminehydrochloride
  • 2-chloro-n-(2-chloroethyl)-ethanaminhydrochloride
CAS:
821-48-7
MF:
C4H10Cl3N
MW:
178.49
EINECS:
212-479-5
Product Categories:
  • Amines, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
  • Pharmaceutical Intermediates
  • Amine Salts
  • Nitrogen Compounds
  • Organic Building Blocks
  • 821-48-7
Mol File:
821-48-7.mol
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Bis(2-chloroethyl)amine hydrochloride Chemical Properties

Melting point:
212-214 °C(lit.)
storage temp. 
Store below +30°C.
solubility 
>100g/l
form 
Crystalline Powder
color 
White to beige
Water Solubility 
SOLUBLE
Sensitive 
Hygroscopic
BRN 
3550356
CAS DataBase Reference
821-48-7(CAS DataBase Reference)
NIST Chemistry Reference
2,2'-Dichlorodiethylamine hydrochloride(821-48-7)
EPA Substance Registry System
Ethanamine, 2-chloro-N-(2-chloroethyl)-, hydrochloride (821-48-7)
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Safety Information

Hazard Codes 
Xi,T,C
Risk Statements 
36/37/38-36-34
Safety Statements 
26-45-36/37/39-27
RIDADR 
2811
WGK Germany 
3
RTECS 
IA1225000
Hazard Note 
Irritant/Toxic
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29211980
Toxicity
LD50 orally in Rabbit: 1150 mg/kg

MSDS

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Bis(2-chloroethyl)amine hydrochloride Usage And Synthesis

Chemical Properties

white to beige crystalline powder

Uses

A cytotoxic metabolite of Cyclophosphamide; a deuterated analog of Nor-nitrogen mustard.

Uses

Bis(2-chloroethyl)amine hydrochloride is used as an intermediate in chemicals synthesis and building block for piperazine derivatives.

Safety Profile

A poison by inhalation,intraperitoneal, intramuscular, and subcutaneous routes.An experimental teratogen. Human mutation datareported. When heated to decomposition it emits toxicfumes of NH3, NOx, and Cl-.

Purification Methods

Crystallise the salt from Me2CO or MeOH/Et2O. The picrate has m 112-113o (from EtOH or Me2CO). [Mann J Chem Soc 464 1934, Ward J Am Chem Soc 57 915 1935,

Bis(2-chloroethyl)amine hydrochlorideSupplier

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